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p(HGNC:SLC5A7)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SLC5A7
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 3

Amyloid Precursor Protein Trafficking, Processing, and Function v1.0.0

Amyloid Precursor Protein Trafficking, Processing, and Function by Thinakaran, et al., 2008

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

In-Edges 3

p(HGNC:APP) regulates act(p(HGNC:SLC5A7)) View Subject | View Object

Furthermore, APP also regulates the presynaptic expression and activity of the high affinity choline transporter. PubMed:18650430

Appears in Networks:
Annotations
Confidence
Medium

complex(p(HGNC:APP), p(HGNC:SLC5A7)) hasComponent p(HGNC:SLC5A7) View Subject | View Object

Appears in Networks:

complex(a(GO:"plasma membrane"), p(HGNC:SLC5A7)) hasComponent p(HGNC:SLC5A7) View Subject | View Object

Appears in Networks:

Out-Edges 5

p(HGNC:SLC5A7) increases a(CHEBI:choline) View Subject | View Object

CHT1 is mainly found in cholinergic neurons [92-94] and is responsible for supplying choline for the synthesis of ACh PubMed:26813123

Appears in Networks:
Annotations
Cell Ontology (CL)
cholinergic neuron

p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) View Subject | View Object

Choline that is released by ACh hydrolysis in the synaptic cleft is continuously reuptaken into the presynaptic cholinergic neuron by an active transport system (see Fig. 1) PubMed:26813123

Appears in Networks:

p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) View Subject | View Object

Two choline transporters have been identified in neurons: a ubiquitous, low-affinity, sodium-independent transporter that can only be inhibited by high concentrations of hemicholinium-3 (HC-3) (Ki of about 50 μM), and a highaffinity, sodium-dependent, HC-3-sensitive (Ki of 10-100 nM) choline transporter (CHT1) PubMed:26813123

Appears in Networks:

p(HGNC:SLC5A7) increases tloc(a(CHEBI:choline), fromLoc(GO:"synaptic cleft"), toLoc(MESH:"Cholinergic Neurons")) View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Membranes
MeSH
Synaptic Vesicles

p(HGNC:SLC5A7) increases a(CHEBI:acetylcholine) View Subject | View Object

It is possible that the presence of CHT1 in the membrane of synaptic vesicles and the consequent increase in CHT1 relocation to the plasma membrane following neuronal depolarization could explain why an increase in neuronal firing promotes increased choline reuptake and, thus, ACh synthesis PubMed:26813123

Appears in Networks:
Annotations
MeSH
Membranes
MeSH
Synaptic Vesicles

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.