path(MESH:"Oxidative Stress")
Activation of M1 mAChR also protects against apoptotic factors in human neuroblastoma SH-SY5Y cells, such as DNA damage, oxidative stress, caspase activation, and mitochondrial impairment[83]. In addition, apoptosis induced by serum deprivation is blocked by M1 mAChR activation in a phosphoinositide 3-kinase- and MAPK/ERKindependent manner PubMed:24590577
Inflammation is one of major pathological changes in AD brains and NF-kB signalling plays an important role in inflammation and oxidative stress (Tong et al. 2005). PubMed:21329555
Oxidative stress and A expression were suppressed with -tocopherol in mouse model. PubMed:29179999
Xanthoceraside alleviated the A 25-35-stimulated spatial memory deficiencies and oxidative stress in mouse models [246]. PubMed:29179999
Beneficial effects of 4-O-methylhonokinol on memory were observed by the reduction of Aaggregation in A 1-42-injected mice and memory-impaired mice with its anti-oxidative and anti-inflammatory qualities [141–143]. PubMed:29179999
Nicorandil, ATP-sensitive potassium channel opener, reduced apo- ptosis and decreased oxidative stress, downregulated APP695 mRNA and APP695 protein expression, also reduced Aβ 42 levels in the medium [90]. PubMed:27288790
Inflammation is one of major pathological changes in AD brains and NF-kB signalling plays an important role in inflammation and oxidative stress (Tong et al. 2005). PubMed:21329555
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