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bp(GO:"NIK/NF-kappaB signaling")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
NIK/NF-kappaB signaling
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease. v1.0.0

Phytochemicals as inhibitors of NF-κB for treatment of Alzheimer’s disease v1.0.0

In-Edges 6

p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"NIK/NF-kappaB signaling") View Subject | View Object

Consistent with NFkB pathway activation and the SASP profile, nuclear localized NFkB p65 was significantly increased in tauNFT brains (Figure 2e-f) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons
MeSH
Alzheimer Disease

p(HGNC:TNF) increases bp(GO:"NIK/NF-kappaB signaling") View Subject | View Object

TNF-a is a strong activator of NF-kB signalling pathways. PubMed:21329555

Appears in Networks:

path(MESH:"Oxidative Stress") association bp(GO:"NIK/NF-kappaB signaling") View Subject | View Object

Inflammation is one of major pathological changes in AD brains and NF-kB signalling plays an important role in inflammation and oxidative stress (Tong et al. 2005). PubMed:21329555

Appears in Networks:

path(MESH:Inflammation) association bp(GO:"NIK/NF-kappaB signaling") View Subject | View Object

Inflammation is one of major pathological changes in AD brains and NF-kB signalling plays an important role in inflammation and oxidative stress (Tong et al. 2005). PubMed:21329555

Appears in Networks:

a(CHEBI:"methyl 3,5-di-O-caffeoyl quinate") decreases bp(GO:"NIK/NF-kappaB signaling") View Subject | View Object

Macranthoin G inhibited the NF-B pathway and activated the phosphorylation of IB, p38 and ERK, and thus, min-imized cell damage [131]. PubMed:29179999

Appears in Networks:

a(CHEBI:lycopene) decreases bp(GO:"NIK/NF-kappaB signaling") View Subject | View Object

It improved ICV A 1-42-activated spatial learning, and memory deficiencies were ameliorated via the interference of NF-B signaling and the inhibition of inflammatory cytokines [155]. PubMed:29179999

Appears in Networks:

Out-Edges 2

bp(GO:"NIK/NF-kappaB signaling") association path(MESH:Inflammation) View Subject | View Object

Inflammation is one of major pathological changes in AD brains and NF-kB signalling plays an important role in inflammation and oxidative stress (Tong et al. 2005). PubMed:21329555

Appears in Networks:

bp(GO:"NIK/NF-kappaB signaling") association path(MESH:"Oxidative Stress") View Subject | View Object

Inflammation is one of major pathological changes in AD brains and NF-kB signalling plays an important role in inflammation and oxidative stress (Tong et al. 2005). PubMed:21329555

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.