1. Catalog
  2. Nodes
  3. a(MESH:"GABAergic Neurons")

a(MESH:"GABAergic Neurons")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
GABAergic Neurons
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 4

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice v1.0.0

Caenorhabditis elegans models of tauopathy v1.0.0

In-Edges 5

act(p(MGI:Chrna7, loc(MESH:Interneurons))) increases act(a(MESH:"GABAergic Neurons")) View Subject | View Object

Mice with a null mutation in the gene that encodes KAT II became a unique tool to resolve this issue (31, 410, 516). Low levels of KYNA in these mutant mice lead to alpha7 nAChR disinhibition in hippocampal CA1 SR interneurons, thereby increasing the activity of GABAergic interneurons impinging onto CA1 pyramidal neurons (31) PubMed:19126755

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
Text Location
Review

a(CHEBI:nicotine) increases act(a(MESH:"GABAergic Neurons")) View Subject | View Object

In mice exposed to chronic nicotine, GABA neurons in substantia nigra pars reticulata have increased baseline firing rates, both in brain slices and in anesthetized animals PubMed:21482353

Appears in Networks:
Annotations
MeSH
Pars Reticulata

a(HBP:"alpha-4 beta-2 nAChR") positiveCorrelation a(MESH:"GABAergic Neurons") View Subject | View Object

In the midbrain, both DA neurons (in substantia nigra pars compacta and ventral tegmental area [VTA]) and GABAergic neurons (in substantia nigra pars reticulata and VTA) express high levels of alpha4beta2* nAChRs on their somata, but only GABAergic neurons display somatic upregulation (Nashmi et al., 2007; Xiao et al., 2009) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Mesencephalon
MeSH
Pars Reticulata
MeSH
Ventral Tegmental Area

a(HBP:"4-OH-GTS-21") causesNoChange a(MESH:"GABAergic Neurons") View Subject | View Object

4OH-GTS-21 had no protective effect on GABAergic neuronal number in this strain, with FFX lesions causing a 34±9% reduction compared with contralateral controls (n=10; P<0.05 compared with unlesioned side, one-way ANOVA). PubMed:17640819

Appears in Networks:

composite(p(HBP:"4R tau", var("p.Lys280del")), p(HBP:"Tau isoform E (412 aa)", var("p.Val337Met"))) decreases a(MESH:"GABAergic Neurons") View Subject | View Object

As a result, the proaggregant lines showed a range of defects including paralysis, axonal degeneration of GABAergic and cholinergic motor neurons, presynaptic defects, synapse loss, and mitochondrial transport defects early in adulthood PubMed:29191965

Appears in Networks:

Out-Edges 1

a(MESH:"GABAergic Neurons") positiveCorrelation a(HBP:"alpha-4 beta-2 nAChR") View Subject | View Object

In the midbrain, both DA neurons (in substantia nigra pars compacta and ventral tegmental area [VTA]) and GABAergic neurons (in substantia nigra pars reticulata and VTA) express high levels of alpha4beta2* nAChRs on their somata, but only GABAergic neurons display somatic upregulation (Nashmi et al., 2007; Xiao et al., 2009) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Mesencephalon
MeSH
Pars Reticulata
MeSH
Ventral Tegmental Area

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.