path(HM:"Heme cytotoxicity")
This result suggested that tyrosine residues of BSA may play an important role in heme detoxification. PubMed:30324533
Importantly, increased expression of FtH also protects different cell types from the cytotoxic effects of heme, TNF or heme and TNF (Balla et al., 1992; Berberat et al., 2003; Cozzi et al., 2003; Gozzelino et al., 2012). PubMed:24904418
For this reason, it has been considered as a therapeutic tool to counteract heme toxic effects in severe hemolytic diseases, and the usefulness of SA therapy has already been demonstrated in a rat model of acute intracerebral hematoma [2, 9]. PubMed:30324533
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.