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p(HBP:"UBB+1")

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Entity

Name
UBB+1
Namespace
HBP
Namespace Version
20190206
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/3c85897632afa791ac78fb3aa2e392963ab155b1/export/hbp-names.belns

Appears in Networks 2

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 4

a(MESH:"Neurofibrillary Tangles") association p(HBP:"UBB+1") View Subject | View Object

A Ub with a 19-residue C-terminal extension from the UBB gene, or UBB+1 (Fig.2A) is selectively expressed in the brains of AD patients (van Leeuwen et al.,1998) and is often found to be accumulated in NFT in Alzheimer’s disease and other tauopathies PubMed:23528736

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1") View Subject | View Object

A Ub with a 19-residue C-terminal extension from the UBB gene, or UBB+1 (Fig.2A) is selectively expressed in the brains of AD patients (van Leeuwen et al.,1998) and is often found to be accumulated in NFT in Alzheimer’s disease and other tauopathies PubMed:23528736

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Alzheimer Disease") positiveCorrelation p(HBP:"UBB+1") View Subject | View Object

UBB+1 protein accumulates in brains affected by AD and other diseases such as Pick’s disease and Huntington’s disease (Fischer et al. 2003). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Niemann-Pick Diseases") positiveCorrelation p(HBP:"UBB+1") View Subject | View Object

UBB+1 protein accumulates in brains affected by AD and other diseases such as Pick’s disease and Huntington’s disease (Fischer et al. 2003). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 12

p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

A Ub with a 19-residue C-terminal extension from the UBB gene, or UBB+1 (Fig.2A) is selectively expressed in the brains of AD patients (van Leeuwen et al.,1998) and is often found to be accumulated in NFT in Alzheimer’s disease and other tauopathies PubMed:23528736

Appears in Networks:
Annotations
MeSH
Brain

p(HBP:"UBB+1") association a(MESH:"Neurofibrillary Tangles") View Subject | View Object

A Ub with a 19-residue C-terminal extension from the UBB gene, or UBB+1 (Fig.2A) is selectively expressed in the brains of AD patients (van Leeuwen et al.,1998) and is often found to be accumulated in NFT in Alzheimer’s disease and other tauopathies PubMed:23528736

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Alzheimer Disease

p(HBP:"UBB+1") decreases bp(GO:"protein deubiquitination") View Subject | View Object

UBB+ 1-capped polyUb chains are resistant to deubiquitination and inhibit proteasomal activity, which may mediate neurodegeneration through mitochondrial stress and p53 activation in neurites (Tan et al., 2007). PubMed:23528736

Appears in Networks:

p(HBP:"UBB+1") decreases act(p(FPLX:Proteasome)) View Subject | View Object

UBB+ 1-capped polyUb chains are resistant to deubiquitination and inhibit proteasomal activity, which may mediate neurodegeneration through mitochondrial stress and p53 activation in neurites (Tan et al., 2007). PubMed:23528736

Appears in Networks:

p(HBP:"UBB+1") increases bp(HP:Neurodegeneration) View Subject | View Object

UBB+ 1-capped polyUb chains are resistant to deubiquitination and inhibit proteasomal activity, which may mediate neurodegeneration through mitochondrial stress and p53 activation in neurites (Tan et al., 2007). PubMed:23528736

Appears in Networks:

p(HBP:"UBB+1") increases bp(MESH:"Stress, Physiological") View Subject | View Object

UBB+ 1-capped polyUb chains are resistant to deubiquitination and inhibit proteasomal activity, which may mediate neurodegeneration through mitochondrial stress and p53 activation in neurites (Tan et al., 2007). PubMed:23528736

Appears in Networks:
Annotations
MeSH
Mitochondria
MeSH
Neurites

p(HBP:"UBB+1") increases act(p(HGNC:TP53)) View Subject | View Object

UBB+ 1-capped polyUb chains are resistant to deubiquitination and inhibit proteasomal activity, which may mediate neurodegeneration through mitochondrial stress and p53 activation in neurites (Tan et al., 2007). PubMed:23528736

Appears in Networks:
Annotations
MeSH
Neurites

p(HBP:"UBB+1") positiveCorrelation path(MESH:"Niemann-Pick Diseases") View Subject | View Object

UBB+1 protein accumulates in brains affected by AD and other diseases such as Pick’s disease and Huntington’s disease (Fischer et al. 2003). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain

p(HBP:"UBB+1") hasVariant p(HBP:"UBB+1", pmod(UbPoly)) View Subject | View Object

Appears in Networks:

p(HBP:"UBB+1") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

UBB+1 protein accumulates in brains affected by AD and other diseases such as Pick’s disease and Huntington’s disease (Fischer et al. 2003). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Brain

p(HBP:"UBB+1") decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") View Subject | View Object

Indeed, transgenic mice expressing UBB+1 have an impaired UPS and show contextual memory deficits in both water maze and fear conditioning paradigms, without specific neuropathological findings (Fischer et al. 2009). PubMed:22908190

Appears in Networks:

p(HBP:"UBB+1") decreases bp(GO:memory) View Subject | View Object

Indeed, transgenic mice expressing UBB+1 have an impaired UPS and show contextual memory deficits in both water maze and fear conditioning paradigms, without specific neuropathological findings (Fischer et al. 2009). PubMed:22908190

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.