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Stress, Physiological
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Appears in Networks 4

In-Edges 1

p(HBP:"UBB+1") increases bp(MESH:"Stress, Physiological") View Subject | View Object

UBB+ 1-capped polyUb chains are resistant to deubiquitination and inhibit proteasomal activity, which may mediate neurodegeneration through mitochondrial stress and p53 activation in neurites (Tan et al., 2007). PubMed:23528736

Out-Edges 3

bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) View Subject | View Object

For instance, dopamine increases in the extended amygdala during stress, fear, and nicotine withdrawal (Inglis and Moghaddam, 1999; Pape, 2005; Grace et al., 2007; Gallagher et al., 2008; Koob, 2009; Marcinkiewcz et al., 2009) PubMed:21482353

bp(MESH:"Stress, Physiological") regulates bp(HBP:Proteostasis) View Subject | View Object

Furthermore, the activity of the PN can be altered permanently or transiently by development and aging, alterations in physiology, or exposure to environmental stress (1). PubMed:25784053

bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.