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bp(MESH:"Stress, Physiological")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Stress, Physiological
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 4

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The Biology of Proteostasis in Aging and Disease v1.0.0

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

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In-Edges 1

p(HBP:"UBB+1") increases bp(MESH:"Stress, Physiological") View Subject | View Object

UBB+ 1-capped polyUb chains are resistant to deubiquitination and inhibit proteasomal activity, which may mediate neurodegeneration through mitochondrial stress and p53 activation in neurites (Tan et al., 2007). PubMed:23528736

Appears in Networks:
Annotations
MeSH
Mitochondria
MeSH
Neurites

Out-Edges 3

bp(MESH:"Stress, Physiological") increases a(CHEBI:dopamine) View Subject | View Object

For instance, dopamine increases in the extended amygdala during stress, fear, and nicotine withdrawal (Inglis and Moghaddam, 1999; Pape, 2005; Grace et al., 2007; Gallagher et al., 2008; Koob, 2009; Marcinkiewcz et al., 2009) PubMed:21482353

Appears in Networks:
Annotations
MeSH
Amygdala

bp(MESH:"Stress, Physiological") regulates bp(HBP:Proteostasis) View Subject | View Object

Furthermore, the activity of the PN can be altered permanently or transiently by development and aging, alterations in physiology, or exposure to environmental stress (1). PubMed:25784053

Appears in Networks:

bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.