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p(HBP:"UBB+1", pmod(UbPoly)) decreases bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process") View Subject | View Object

The resulting polyubiquitinated UBB+1 cannot be degraded by proteasomes and impairs the UPS (Lam et al. 2000), which may induce neurotoxicity. PubMed:22908190

p(HBP:"UBB+1", pmod(UbPoly)) decreases deg(p(HBP:"UBB+1", pmod(UbPoly))) View Subject | View Object

The resulting polyubiquitinated UBB+1 cannot be degraded by proteasomes and impairs the UPS (Lam et al. 2000), which may induce neurotoxicity. PubMed:22908190

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.