1. Catalog
  2. Nodes
  3. a(HBP:HBP00071)

a(HBP:HBP00071)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00071
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 3

Amyloid Precursor Protein Trafficking, Processing, and Function v1.0.0

Amyloid Precursor Protein Trafficking, Processing, and Function by Thinakaran, et al., 2008

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 5

complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) View Subject | View Object

As mentioned above, γ-secretase processing of APP also releases AICD (Fig. 1). PubMed:18650430

Appears in Networks:
Annotations
Confidence
High

p(HGNC:APBB1) increases a(HBP:HBP00071) View Subject | View Object

Moreover, Fe65 stabilizes the highly labile AICD, which may serve as a regulatory step in modulating the physiological func- tion of AICD (see below). PubMed:18650430

Appears in Networks:
Annotations
Confidence
High

complex(FPLX:"Gamma_secretase") increases a(HBP:HBP00071) View Subject | View Object

Accordingly, various AICDs (C50, C53, C57 and C59) can be generated during these multi-site cleavages executed by gamma-secretase. However, all of the endogenous AICD forms are rarely detected, probably because of their very rapid degradation (Lu et al. 2000; Passer et al. 2000; Sastre et al. 2001; Yu et al. 2001; Sato et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

rxn(reactants(a(HBP:HBP00072)), products(a(HBP:HBP00071), a(HBP:HBP00080))) hasProduct a(HBP:HBP00071) View Subject | View Object

Appears in Networks:

rxn(reactants(a(HBP:HBP00081)), products(a(HBP:HBP00071), a(MESH:"Amyloid beta-Peptides"))) hasProduct a(HBP:HBP00071) View Subject | View Object

Appears in Networks:

Out-Edges 8

act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:APP) View Subject | View Object

In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK- 3b, KAI1, neprilysin, BACE1, p53, EGFR, and LRP1 [127-132] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Medium
MeSH
Neurons

act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:GSK3B) View Subject | View Object

In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK- 3b, KAI1, neprilysin, BACE1, p53, EGFR, and LRP1 [127-132] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Medium
MeSH
Neurons

act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:CD82) View Subject | View Object

In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK- 3b, KAI1, neprilysin, BACE1, p53, EGFR, and LRP1 [127-132] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Medium
MeSH
Neurons

act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:MME) View Subject | View Object

In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK- 3b, KAI1, neprilysin, BACE1, p53, EGFR, and LRP1 [127-132] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Medium
MeSH
Neurons

act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:BACE1) View Subject | View Object

In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK- 3b, KAI1, neprilysin, BACE1, p53, EGFR, and LRP1 [127-132] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Medium
MeSH
Neurons

act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:EGFR) View Subject | View Object

In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK- 3b, KAI1, neprilysin, BACE1, p53, EGFR, and LRP1 [127-132] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Medium
MeSH
Neurons

act(a(HBP:HBP00071), ma(tscript)) regulates p(HGNC:LRP1) View Subject | View Object

In a similar fashion, released AICD has been shown to possess transactivation activity and can regulate transcription of multiple genes including APP, GSK- 3b, KAI1, neprilysin, BACE1, p53, EGFR, and LRP1 [127-132] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Medium
MeSH
Neurons

a(HBP:HBP00071) increases bp(GO:"apoptotic process") View Subject | View Object

In addition, free AICD can induce apoptosis and may play a role in sensitizing neurons to toxic stimuli [133,134] PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.