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a(GO:"microtubule cytoskeleton")

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Entity

Name
microtubule cytoskeleton
Namespace
go
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/a5b84013a08880975ca84f40999e4404b14a97e2/external/go-names.belns

Appears in Networks 3

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

Caenorhabditis elegans models of tauopathy v1.0.0

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 6

act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton") View Subject | View Object

Apart from affecting tau phosphorylation, abnormal activation of GSK3β, cdk5, and ERK has been linked to cytoskeletal abnormalities (microtubules, neurofilaments), alterations in amyloid precursor protein (APP) phosphorylation and processing, impairment of neurogenesis, alterations in synaptic plasticity and induction of apoptotic processes (Reviewed in Crews and Masliah, 2010; Medina and Avila, 2013, 2014). PubMed:24653673

Appears in Networks:

act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton") View Subject | View Object

Apart from affecting tau phosphorylation, abnormal activation of GSK3β, cdk5, and ERK has been linked to cytoskeletal abnormalities (microtubules, neurofilaments), alterations in amyloid precursor protein (APP) phosphorylation and processing, impairment of neurogenesis, alterations in synaptic plasticity and induction of apoptotic processes (Reviewed in Crews and Masliah, 2010; Medina and Avila, 2013, 2014). PubMed:24653673

Appears in Networks:

act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton") View Subject | View Object

Apart from affecting tau phosphorylation, abnormal activation of GSK3β, cdk5, and ERK has been linked to cytoskeletal abnormalities (microtubules, neurofilaments), alterations in amyloid precursor protein (APP) phosphorylation and processing, impairment of neurogenesis, alterations in synaptic plasticity and induction of apoptotic processes (Reviewed in Crews and Masliah, 2010; Medina and Avila, 2013, 2014). PubMed:24653673

Appears in Networks:

bp(GO:"cellular response to mechanical stimulus") decreases a(GO:"microtubule cytoskeleton") View Subject | View Object

A recent study, Krieg et al. (49), established the role of PTL-1 in the maintenance and repair of the microtubule cytoskeleton after transient damage induced by mechanical stress. This process requires other microtubule-associated proteins such as b-spectrin. PubMed:29191965

Appears in Networks:

composite(p(HGNC:MAPT), p(HGNC:SPTB)) regulates a(GO:"microtubule cytoskeleton") View Subject | View Object

A recent study, Krieg et al. (49), established the role of PTL-1 in the maintenance and repair of the microtubule cytoskeleton after transient damage induced by mechanical stress. This process requires other microtubule-associated proteins such as b-spectrin. PubMed:29191965

Appears in Networks:

p(HGNC:DTNBP1) association a(GO:"microtubule cytoskeleton") View Subject | View Object

In particular, CRMP2 is a cytosolic protein enriched in the CNS, which has been implicated in microtubule stabilization, and thus in the regulation of cytoskeletal dynamics and vesicle trafficking PubMed:30061532

Appears in Networks:

Out-Edges 4

a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B)) View Subject | View Object

Apart from affecting tau phosphorylation, abnormal activation of GSK3β, cdk5, and ERK has been linked to cytoskeletal abnormalities (microtubules, neurofilaments), alterations in amyloid precursor protein (APP) phosphorylation and processing, impairment of neurogenesis, alterations in synaptic plasticity and induction of apoptotic processes (Reviewed in Crews and Masliah, 2010; Medina and Avila, 2013, 2014). PubMed:24653673

Appears in Networks:

a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5)) View Subject | View Object

Apart from affecting tau phosphorylation, abnormal activation of GSK3β, cdk5, and ERK has been linked to cytoskeletal abnormalities (microtubules, neurofilaments), alterations in amyloid precursor protein (APP) phosphorylation and processing, impairment of neurogenesis, alterations in synaptic plasticity and induction of apoptotic processes (Reviewed in Crews and Masliah, 2010; Medina and Avila, 2013, 2014). PubMed:24653673

Appears in Networks:

a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK)) View Subject | View Object

Apart from affecting tau phosphorylation, abnormal activation of GSK3β, cdk5, and ERK has been linked to cytoskeletal abnormalities (microtubules, neurofilaments), alterations in amyloid precursor protein (APP) phosphorylation and processing, impairment of neurogenesis, alterations in synaptic plasticity and induction of apoptotic processes (Reviewed in Crews and Masliah, 2010; Medina and Avila, 2013, 2014). PubMed:24653673

Appears in Networks:

a(GO:"microtubule cytoskeleton") association p(HGNC:DTNBP1) View Subject | View Object

In particular, CRMP2 is a cytosolic protein enriched in the CNS, which has been implicated in microtubule stabilization, and thus in the regulation of cytoskeletal dynamics and vesicle trafficking PubMed:30061532

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.