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p(HGNC:DTNBP1)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
DTNBP1
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/efc856fb009a39e4d284269a6801f79ed3d3cf56/external/hgnc-names.belns

Appears in Networks 1

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 7

a(GO:"microtubule cytoskeleton") association p(HGNC:DTNBP1) View Subject | View Object

In particular, CRMP2 is a cytosolic protein enriched in the CNS, which has been implicated in microtubule stabilization, and thus in the regulation of cytoskeletal dynamics and vesicle trafficking PubMed:30061532

Appears in Networks:

act(a(GO:cytoskeleton)) association p(HGNC:DTNBP1) View Subject | View Object

In particular, CRMP2 is a cytosolic protein enriched in the CNS, which has been implicated in microtubule stabilization, and thus in the regulation of cytoskeletal dynamics and vesicle trafficking PubMed:30061532

Appears in Networks:

bp(GO:"synaptic vesicle transport") association p(HGNC:DTNBP1) View Subject | View Object

In particular, CRMP2 is a cytosolic protein enriched in the CNS, which has been implicated in microtubule stabilization, and thus in the regulation of cytoskeletal dynamics and vesicle trafficking PubMed:30061532

Appears in Networks:

complex(a(GO:"actin cytoskeleton"), p(HGNC:DTNBP1)) hasComponent p(HGNC:DTNBP1) View Subject | View Object

Appears in Networks:

complex(a(GO:microtubule), p(HGNC:DTNBP1)) hasComponent p(HGNC:DTNBP1) View Subject | View Object

Appears in Networks:

path(MESH:Schizophrenia) association p(HGNC:DTNBP1) View Subject | View Object

Preliminary in vitro studies demonstrated that two proteins, namely DISC1 and dysbindin-1, which are encoded by two susceptibility genes for schizophrenia, can form insoluble protein aggregates that are reminiscent of those occurring in neurodegenerative disorders PubMed:30061532

Appears in Networks:

path(MESH:Schizophrenia) association p(HGNC:DTNBP1) View Subject | View Object

Intriguingly, the interactome analysis of both DISC1, dysbindin-1, and CRMP2, which is another susceptibility gene for schizophrenia, revealed common protein interactions with microtubules, actin cytoskeleton, and proteins involved in intracellular transport PubMed:30061532

Appears in Networks:

Out-Edges 6

p(HGNC:DTNBP1) association path(MESH:Schizophrenia) View Subject | View Object

Preliminary in vitro studies demonstrated that two proteins, namely DISC1 and dysbindin-1, which are encoded by two susceptibility genes for schizophrenia, can form insoluble protein aggregates that are reminiscent of those occurring in neurodegenerative disorders PubMed:30061532

Appears in Networks:

p(HGNC:DTNBP1) association path(MESH:Schizophrenia) View Subject | View Object

Intriguingly, the interactome analysis of both DISC1, dysbindin-1, and CRMP2, which is another susceptibility gene for schizophrenia, revealed common protein interactions with microtubules, actin cytoskeleton, and proteins involved in intracellular transport PubMed:30061532

Appears in Networks:

p(HGNC:DTNBP1) increases a(HBP:"protein aggregates") View Subject | View Object

Preliminary in vitro studies demonstrated that two proteins, namely DISC1 and dysbindin-1, which are encoded by two susceptibility genes for schizophrenia, can form insoluble protein aggregates that are reminiscent of those occurring in neurodegenerative disorders PubMed:30061532

Appears in Networks:

p(HGNC:DTNBP1) association a(GO:"microtubule cytoskeleton") View Subject | View Object

In particular, CRMP2 is a cytosolic protein enriched in the CNS, which has been implicated in microtubule stabilization, and thus in the regulation of cytoskeletal dynamics and vesicle trafficking PubMed:30061532

Appears in Networks:

p(HGNC:DTNBP1) association act(a(GO:cytoskeleton)) View Subject | View Object

In particular, CRMP2 is a cytosolic protein enriched in the CNS, which has been implicated in microtubule stabilization, and thus in the regulation of cytoskeletal dynamics and vesicle trafficking PubMed:30061532

Appears in Networks:

p(HGNC:DTNBP1) association bp(GO:"synaptic vesicle transport") View Subject | View Object

In particular, CRMP2 is a cytosolic protein enriched in the CNS, which has been implicated in microtubule stabilization, and thus in the regulation of cytoskeletal dynamics and vesicle trafficking PubMed:30061532

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.