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p(MGI:Syp)

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Entity

Name
Syp
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 4

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 v1.0.0

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

p(MGI:Chrna7) decreases p(MGI:Syp) View Subject | View Object

In the APP-alpha7KO line the lack of alpha7 was sufficient to preserve synaptic terminals and dendrites, rescuing levels of synaptophysin and MAP2 to reach that of aged-matched WT controls PubMed:25514383

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) View Subject | View Object

Furthermore, we did not see colocalization of the grains of Tau and presynaptic marker synaptophysin (Fig. S3) PubMed:27671637

Appears in Networks:

composite(a(CHEBI:"dasatinib (anhydrous)"), a(CHEBI:quercetin)) increases p(MGI:Syp) View Subject | View Object

DQ-treated mice expressed significantly higher levels of neuronal proteins (NeuN: 25%, synaptophysin: 40.8%; PSD95: 38.5%; P < 0.05; Figure 5f-i) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

p(MGI:Hpx) increases p(MGI:Syp) View Subject | View Object

It further increases the expression of a marker for resting HSCs, synaptophysin, and reduces the expression of a marker for activated myofibroblast-like HSCs, smooth muscle actin (SMA) (Figure 7B). PubMed:26675351

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Liver
MeSH
Anemia, Sickle Cell
Text Location
Results

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.