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a(HP:"Argyrophilic inclusion bodies")

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Entity

Name
Argyrophilic inclusion bodies
Namespace
HP
Namespace Version
2017-10-05
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns

Appears in Networks 1

Adenosine A1 receptor antagonist 64627 alleviates axonopathy caused by human Tau ΔK280 v1.0.0

In-Edges 3

composite(a(HP:"Argyrophilic inclusion bodies"), p(MGI:Mapt)) hasComponent a(HP:"Argyrophilic inclusion bodies") View Subject | View Object

Appears in Networks:

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) association a(HP:"Argyrophilic inclusion bodies") View Subject | View Object

Only proaggregant Tau transgenic slices reveal Taupositive beaded structures in the neuropil oriented mostly perpendicular to the apical dendrites of the CA1 pyramidal cells (Fig. 1 C and D, arrowheads) resembling grains in human AGD (16) PubMed:27671637

Appears in Networks:
Annotations
Cell Ontology (CL)
pyramidal neuron
MeSH
CA1 Region, Hippocampal

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) positiveCorrelation a(HP:"Argyrophilic inclusion bodies") View Subject | View Object

This suggests that proaggregant Tau accumulates in the axons as grains PubMed:27671637

Appears in Networks:
Annotations
MeSH
Axons

Out-Edges 3

a(HP:"Argyrophilic inclusion bodies") association p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

Only proaggregant Tau transgenic slices reveal Taupositive beaded structures in the neuropil oriented mostly perpendicular to the apical dendrites of the CA1 pyramidal cells (Fig. 1 C and D, arrowheads) resembling grains in human AGD (16) PubMed:27671637

Appears in Networks:
Annotations
Cell Ontology (CL)
pyramidal neuron
MeSH
CA1 Region, Hippocampal

a(HP:"Argyrophilic inclusion bodies") positiveCorrelation p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) View Subject | View Object

This suggests that proaggregant Tau accumulates in the axons as grains PubMed:27671637

Appears in Networks:
Annotations
MeSH
Axons

a(HP:"Argyrophilic inclusion bodies") causesNoChange p(MGI:Syp) View Subject | View Object

Furthermore, we did not see colocalization of the grains of Tau and presynaptic marker synaptophysin (Fig. S3) PubMed:27671637

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.