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complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))

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Components

Appears in Networks 2

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

In-Edges 7

a(MESH:Conotoxins) association complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) View Subject | View Object

Regarding the ascending afferent excitatory pain pathway, in which nicotinic antagonists are anticipated to have analgesic effects, a newly described subtype of nAChR, α9α10, seems to be expressed on dorsal root ganglia (in addition to the inner ear) and constitutes an in vitro target for new α-conotoxins, such as vc1.1, RgiA, or it14a237–241. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

a(MESH:Conotoxins) decreases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) View Subject | View Object

In vivo, these α-conotoxins display potent alleviation of allopathic pain239,242,243 (and additionally reveal an endogeneous ACh activation of lymphocytes through α9α10 nAChRs, which are inhibited by these α-conotoxins). PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

a(MESH:"Ganglia, Spinal") increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) View Subject | View Object

α9 or a9 and α10 subunits are expressed in most immune cells, dorsal root ganglion cells, human keratinocytes and colon and breast cancer cells. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Acetylcholine) increases act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) View Subject | View Object

α9 and α9-α10 nAChRs have a number of interesting characteristics: they are acti- vated by ACh but not by the classical agonist nicotine. Cho- line is also a potent selective agonist of the α9 subtype PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Keratinocytes) increases complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) View Subject | View Object

α9 or a9 and α10 subunits are expressed in most immune cells, dorsal root ganglion cells, human keratinocytes and colon and breast cancer cells. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Nicotine) causesNoChange act(complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9))) View Subject | View Object

α9 and α9-α10 nAChRs have a number of interesting characteristics: they are acti- vated by ACh but not by the classical agonist nicotine. Cho- line is also a potent selective agonist of the α9 subtype PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

a(MESH:Phosphorylcholine) causesNoChange complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) View Subject | View Object

whereas phosphocholine (PC) does not evoke ion current responses in Xenopus oocytes expressing functional ho- momeric α9 or heteromeric α9-α10 nAChRs [121]. How- ever, preincubation with PC attenuates choline-induced ion current changes, thus suggesting that PC is a silent agonist of these two subtypes PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

Out-Edges 5

complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) hasComponent p(HGNC:CHRNA10) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) hasComponent p(HGNC:CHRNA9) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) association a(MESH:Conotoxins) View Subject | View Object

Regarding the ascending afferent excitatory pain pathway, in which nicotinic antagonists are anticipated to have analgesic effects, a newly described subtype of nAChR, α9α10, seems to be expressed on dorsal root ganglia (in addition to the inner ear) and constitutes an in vitro target for new α-conotoxins, such as vc1.1, RgiA, or it14a237–241. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases act(a(MESH:Lymphocytes)) View Subject | View Object

In vivo, these α-conotoxins display potent alleviation of allopathic pain239,242,243 (and additionally reveal an endogeneous ACh activation of lymphocytes through α9α10 nAChRs, which are inhibited by these α-conotoxins). PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

complex(p(HGNC:CHRNA10), p(HGNC:CHRNA9)) increases p(MESH:"Receptors, Nicotinic") View Subject | View Object

Unlike the α9 subunit, the α10 subunit is only functional when it is co-expressed with an α9 subunit. In Xenopus oocytes, the co-injection of α9 and α10 subunits increases functional nAChR expression at least 100 times more than the injection of α9 alone. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.