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bp(GO:"regulation of endosome size")

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Entity

Name
regulation of endosome size
Namespace
go
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/a5b84013a08880975ca84f40999e4404b14a97e2/external/go-names.belns

Appears in Networks 1

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 6

a(HBP:"Braak_Stage II") association bp(GO:"regulation of endosome size") View Subject | View Object

Neuronal endosome enlargement, which is not characteristically observed in other major neurodegenerative diseases, develops in pyramidal neurons of the neocortex at a stage when plaques and tangles are restricted only to the hippocampus (Braak stage 2) and not in brains of similarly aged individuals free of AD-like hippocampal pathology (Cataldo et al. 1997, 2000). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Neurons
MeSH
Pyramidal Cells

p(HGNC:RAB4A) association bp(GO:"regulation of endosome size") View Subject | View Object

Genes related to endocytosis, such as Rab5,Rab7, and Rab4, are among the earliest groups to showup-regulated transcription in AD(Ginsberg et al. 2010), and their corresponding proteins are abnormally recruited to endosomes, where they promote fusion and abnormal enlargement of early and late endosomes (Cataldo et al. 1997, 2008). PubMed:22908190

Appears in Networks:

p(HGNC:RAB5A) association bp(GO:"regulation of endosome size") View Subject | View Object

Genes related to endocytosis, such as Rab5,Rab7, and Rab4, are among the earliest groups to showup-regulated transcription in AD(Ginsberg et al. 2010), and their corresponding proteins are abnormally recruited to endosomes, where they promote fusion and abnormal enlargement of early and late endosomes (Cataldo et al. 1997, 2008). PubMed:22908190

Appears in Networks:

p(HGNC:RAB7A) association bp(GO:"regulation of endosome size") View Subject | View Object

Genes related to endocytosis, such as Rab5,Rab7, and Rab4, are among the earliest groups to showup-regulated transcription in AD(Ginsberg et al. 2010), and their corresponding proteins are abnormally recruited to endosomes, where they promote fusion and abnormal enlargement of early and late endosomes (Cataldo et al. 1997, 2008). PubMed:22908190

Appears in Networks:

path(MESH:"Down Syndrome") negativeCorrelation bp(GO:"regulation of endosome size") View Subject | View Object

Similar endosomal anomalies develop gradually in Down syndrome brain, beginning decades before the appearance of classical AD pathology (Cataldo et al. 2000). PubMed:22908190

Appears in Networks:

path(MESH:"Neurodegenerative Diseases") association bp(GO:"regulation of endosome size") View Subject | View Object

Neuronal endosome enlargement, which is not characteristically observed in other major neurodegenerative diseases, develops in pyramidal neurons of the neocortex at a stage when plaques and tangles are restricted only to the hippocampus (Braak stage 2) and not in brains of similarly aged individuals free of AD-like hippocampal pathology (Cataldo et al. 1997, 2000). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Neurons
MeSH
Pyramidal Cells

Out-Edges 6

bp(GO:"regulation of endosome size") association path(MESH:"Neurodegenerative Diseases") View Subject | View Object

Neuronal endosome enlargement, which is not characteristically observed in other major neurodegenerative diseases, develops in pyramidal neurons of the neocortex at a stage when plaques and tangles are restricted only to the hippocampus (Braak stage 2) and not in brains of similarly aged individuals free of AD-like hippocampal pathology (Cataldo et al. 1997, 2000). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Neurons
MeSH
Pyramidal Cells

bp(GO:"regulation of endosome size") association a(HBP:"Braak_Stage II") View Subject | View Object

Neuronal endosome enlargement, which is not characteristically observed in other major neurodegenerative diseases, develops in pyramidal neurons of the neocortex at a stage when plaques and tangles are restricted only to the hippocampus (Braak stage 2) and not in brains of similarly aged individuals free of AD-like hippocampal pathology (Cataldo et al. 1997, 2000). PubMed:22908190

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Neurons
MeSH
Pyramidal Cells

bp(GO:"regulation of endosome size") negativeCorrelation path(MESH:"Down Syndrome") View Subject | View Object

Similar endosomal anomalies develop gradually in Down syndrome brain, beginning decades before the appearance of classical AD pathology (Cataldo et al. 2000). PubMed:22908190

Appears in Networks:

bp(GO:"regulation of endosome size") association p(HGNC:RAB7A) View Subject | View Object

Genes related to endocytosis, such as Rab5,Rab7, and Rab4, are among the earliest groups to showup-regulated transcription in AD(Ginsberg et al. 2010), and their corresponding proteins are abnormally recruited to endosomes, where they promote fusion and abnormal enlargement of early and late endosomes (Cataldo et al. 1997, 2008). PubMed:22908190

Appears in Networks:

bp(GO:"regulation of endosome size") association p(HGNC:RAB5A) View Subject | View Object

Genes related to endocytosis, such as Rab5,Rab7, and Rab4, are among the earliest groups to showup-regulated transcription in AD(Ginsberg et al. 2010), and their corresponding proteins are abnormally recruited to endosomes, where they promote fusion and abnormal enlargement of early and late endosomes (Cataldo et al. 1997, 2008). PubMed:22908190

Appears in Networks:

bp(GO:"regulation of endosome size") association p(HGNC:RAB4A) View Subject | View Object

Genes related to endocytosis, such as Rab5,Rab7, and Rab4, are among the earliest groups to showup-regulated transcription in AD(Ginsberg et al. 2010), and their corresponding proteins are abnormally recruited to endosomes, where they promote fusion and abnormal enlargement of early and late endosomes (Cataldo et al. 1997, 2008). PubMed:22908190

Appears in Networks:

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.