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path(MESH:Sepsis)

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Entity

Name
Sepsis
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 2

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 10

a(CHEBI:"oxygen radical") positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Hemodynamics will be impaired, which on the one hand can lead to the production of oxygen radicals and thus directly to tissue damage. PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

a(HM:"Impaired microcirculation") positiveCorrelation path(MESH:Sepsis) View Subject | View Object

One crucial factor in pathogenesis of systemic inflammation/sepsis is an impaired microcirculation [99]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

bp(MESH:Eryptosis) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

In 2007, Kempe10 et al. reported that erythrocytes showed an apoptotic tendency in septic patients. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
Text Location
Introduction

path(MESH:Hemolysis) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Thus, hemolysis can act as a kind of amplifier of the complex response to an infection or injury [8, 15] and worsen the outcome from animals and patients with systemic inflammation, sepsis, or trauma [1–4, 10]. PubMed:29956069

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Text Location
Review

path(MESH:Hemolysis) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Both clinical [1–4] and experimental [5–8] studies have shown that sepsis and systemic inflammation lead to a massive release of hemoglobin from red blood cells (hemolysis) being accompanied with an increased risk of death [1–4, 8, 9]. PubMed:29956069

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Text Location
Review

path(MESH:Hyperventilation) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

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Text Location
Review

path(MESH:Hypothermia) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Leukocytosis) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Leukopenia) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Tachycardia) positiveCorrelation path(MESH:Sepsis) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

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Text Location
Review

Out-Edges 12

path(MESH:Sepsis) increases bp(GO:"protein catabolic process") View Subject | View Object

For example, upregulation of the pathway is observed during massive degradation of skeletal muscle proteins that occurs under normal fasting but also under pathological conditions such as cancer-induced cachexia, severe sepsis, metabolic acidosis, or following denervation PubMed:14556719

Appears in Networks:
Annotations
MeSH
Muscle, Skeletal

path(MESH:Sepsis) positiveCorrelation bp(MESH:Eryptosis) View Subject | View Object

In 2007, Kempe10 et al. reported that erythrocytes showed an apoptotic tendency in septic patients. PubMed:29544683

Appears in Networks:
Annotations
MeSH
Erythrocyte Membrane
Text Location
Introduction

path(MESH:Sepsis) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Both clinical [1–4] and experimental [5–8] studies have shown that sepsis and systemic inflammation lead to a massive release of hemoglobin from red blood cells (hemolysis) being accompanied with an increased risk of death [1–4, 8, 9]. PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Sepsis) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Thus, hemolysis can act as a kind of amplifier of the complex response to an infection or injury [8, 15] and worsen the outcome from animals and patients with systemic inflammation, sepsis, or trauma [1–4, 10]. PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Sepsis) positiveCorrelation path(MESH:Hypothermia) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Sepsis) positiveCorrelation path(MESH:Tachycardia) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Sepsis) positiveCorrelation path(MESH:Hyperventilation) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Sepsis) positiveCorrelation path(MESH:Leukocytosis) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Sepsis) positiveCorrelation path(MESH:Leukopenia) View Subject | View Object

Crucial for a sepsis, thus, was the presence of at least two of four criteria of a systemic inflammatory response syndrome (SIRS), which includes (1) fever (≥ 38.0 °C) or hypothermia (≤ 36.0 °C), (2) tachycardia (heart rate ≥ 90/min), (3) tachypnea (frequency ≥ 20/min) or hyperventilation, and (4) leukocytosis (white blood cells ≥ 12,000/mm3) or leukopenia (white blood cells ≤ 4000/mm3). PubMed:29956069

Appears in Networks:
Annotations
Text Location
Review

path(MESH:Sepsis) positiveCorrelation a(CHEBI:"oxygen radical") View Subject | View Object

Hemodynamics will be impaired, which on the one hand can lead to the production of oxygen radicals and thus directly to tissue damage. PubMed:29956069

Appears in Networks:
Annotations
MeSH
Arteries
MeSH
Sepsis
Text Location
Review

path(MESH:Sepsis) decreases path(MESH:Fibrinolysis) View Subject | View Object

Furthermore, fibrinolysis (dissolution of a blood clot) is also regularly inhibited in the early stages of sepsis [86]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Sepsis
Text Location
Review

path(MESH:Sepsis) positiveCorrelation a(HM:"Impaired microcirculation") View Subject | View Object

One crucial factor in pathogenesis of systemic inflammation/sepsis is an impaired microcirculation [99]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Microvessels
MeSH
Disseminated Intravascular Coagulation
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.