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bp(GO:"canonical Wnt signaling pathway")

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Entity

Name
canonical Wnt signaling pathway
Namespace
go
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/go-names.belns

Appears in Networks 1

A role for APP in Wnt signalling links synapse loss with β-amyloid production. v1.0.0

In-Edges 9

bp(GO:"amyloid-beta formation") negativeCorrelation bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

Comparison of signalling activity and Aβ production under each of the different conditions showed clearly that Aβ production was negatively correlated with Wnt-β-catenin signalling activity (Fig. 2d) and positively correlated with Wnt-PCP signalling (Fig. 2e). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

p(HGNC:APP) increases bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

In contrast with wild-type APP which, as before, potentiated both canonical and non-canonical Wnt signalling, the Swedish mutant form of APP antagonised canonical Wnt signalling (Fig. 2a), and potentiated non-canonical Wnt signalling to a greater degree than wild-type APP (APPWT) (Fig. 2b). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

p(HGNC:LRP6) association bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

APP has previously been shown to interact with Vangl2, a Wnt-PCP-specific co-receptor protein, and independently has been shown to bind LRP6, a receptor component of the Wnt-β-catenin pathway21. PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:DKK1)) decreases bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

Overexpression of APP enhanced the inhibitory effects of Dkk1 on Wnt3a induced Wnt-β-catenin signalling, counteracting the enhanced activity resulting from APP overexpression and reducing the IC50 of Dkk1 to 122ng/mL from 173ng/mL in the absence of APP (Fig. 2f) . PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

composite(p(HGNC:APP), p(HGNC:LRP6)) increases bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

The ability of APP to potentiate Wnt-β-catenin signalling in response to Wnt3a was enhanced by the overexpression of LRP6, and attenuated by Vangl2 (Fig. 1g). PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

composite(p(HGNC:APP), p(HGNC:VANGL2)) decreases bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

The ability of APP to potentiate Wnt-β-catenin signalling in response to Wnt3a was enhanced by the overexpression of LRP6, and attenuated by Vangl2 (Fig. 1g). PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) decreases bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

In contrast with wild-type APP which, as before, potentiated both canonical and non-canonical Wnt signalling, the Swedish mutant form of APP antagonised canonical Wnt signalling (Fig. 2a), and potentiated non-canonical Wnt signalling to a greater degree than wild-type APP (APPWT) (Fig. 2b). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

APP did though potentiate both Wnt3a-driven Wnt-β-catenin signalling and Wnt5a-driven Wnt-PCP signalling. PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

Overexpression of APP enhanced the inhibitory effects of Dkk1 on Wnt3a induced Wnt-β-catenin signalling, counteracting the enhanced activity resulting from APP overexpression and reducing the IC50 of Dkk1 to 122ng/mL from 173ng/mL in the absence of APP (Fig. 2f) . PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

Out-Edges 3

bp(GO:"canonical Wnt signaling pathway") association p(HGNC:LRP6) View Subject | View Object

APP has previously been shown to interact with Vangl2, a Wnt-PCP-specific co-receptor protein, and independently has been shown to bind LRP6, a receptor component of the Wnt-β-catenin pathway21. PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

bp(GO:"canonical Wnt signaling pathway") decreases a(CHEBI:"amyloid-beta") View Subject | View Object

In cells expressing either wild-type or Swedish APP, the amount of Aβ produced was reduced in cells stimulated with Wnt3a, which promotes Wnt-βcatenin signalling, whereas Aβ production was enhanced in cells stimulated with Wnt5a, which promotes Wnt-PCP signalling (Fig. 2c). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

bp(GO:"canonical Wnt signaling pathway") negativeCorrelation bp(GO:"amyloid-beta formation") View Subject | View Object

Comparison of signalling activity and Aβ production under each of the different conditions showed clearly that Aβ production was negatively correlated with Wnt-β-catenin signalling activity (Fig. 2d) and positively correlated with Wnt-PCP signalling (Fig. 2e). PubMed:30232325

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.