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composite(p(HGNC:APP), p(HGNC:LRP6))

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Components

Appears in Networks 1

A role for APP in Wnt signalling links synapse loss with β-amyloid production. v1.0.0

In-Edges 0

Out-Edges 5

composite(p(HGNC:APP), p(HGNC:LRP6)) hasComponent p(HGNC:APP) View Subject | View Object

Appears in Networks:

composite(p(HGNC:APP), p(HGNC:LRP6)) hasComponent p(HGNC:LRP6) View Subject | View Object

Appears in Networks:

composite(p(HGNC:APP), p(HGNC:LRP6)) increases bp(GO:"canonical Wnt signaling pathway") View Subject | View Object

The ability of APP to potentiate Wnt-β-catenin signalling in response to Wnt3a was enhanced by the overexpression of LRP6, and attenuated by Vangl2 (Fig. 1g). PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

composite(p(HGNC:APP), p(HGNC:LRP6)) decreases bp(GO:"Wnt signaling pathway, planar cell polarity pathway") View Subject | View Object

Conversely, the ability of APP to potentiate Wnt-PCP signalling in response to Wnt5a was enhanced by Vangl2 and attenuated by LRP6 (Fig. 1h). PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

composite(p(HGNC:APP), p(HGNC:LRP6)) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Co-expression of LRP6 with APP reduced the production of Aβ, while co-expression of Vangl2 with APP led to increased Aβ production (Fig. 2c). PubMed:30232325

Appears in Networks:
Annotations
Confidence
Medium

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.