p(HGNC:APP) increases bp(GO:"canonical Wnt signaling pathway")

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PubMed:30232325

In contrast with wild-type APP which, as before, potentiated both canonical and non-canonical Wnt signalling, the Swedish mutant form of APP antagonised canonical Wnt signalling (Fig. 2a), and potentiated non-canonical Wnt signalling to a greater degree than wild-type APP (APPWT) (Fig. 2b).

Related Edges 3

• p(HGNC:APP) increases bp(GO:"non-canonical Wnt signaling pathway")
• p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) decreases bp(GO:"canonical Wnt signaling pathway")
• p(HGNC:APP, var("p.Lys670Asn"), var("p.Met671Leu")) increases bp(GO:"non-canonical Wnt signaling pathway")

Confidence

High

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