act(p(HGNC:DKK1)) decreases bp(GO:"canonical Wnt signaling pathway")

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PubMed:30232325

Overexpression of APP enhanced the inhibitory effects of Dkk1 on Wnt3a induced Wnt-β-catenin signalling, counteracting the enhanced activity resulting from APP overexpression and reducing the IC50 of Dkk1 to 122ng/mL from 173ng/mL in the absence of APP (Fig. 2f) .

Related Edges 3

• p(HGNC:APP) increases act(p(HGNC:DKK1))
• act(p(HGNC:DKK1)) decreases act(p(HGNC:WNT3A))
• act(p(HGNC:WNT3A)) increases bp(GO:"canonical Wnt signaling pathway")

Confidence

Medium

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