p(FPLX:PPP2C)

Components

• p(HGNC:PPP2CA)
• p(HGNC:PPP2CB)

Entity

Name

PPP2C

Namespace

FPLX

Namespace Version

20180917

Namespace URL

https://raw.githubusercontent.com/sorgerlab/famplex/e8ae9926ff95266032cb74f77973c84939bffbeb/export/famplex.belns

Potent tumor promoter, Okadaic acid (a microbial toxin), inhibits the enzymatic activity of PP2Ac and thereby has facilitated various studies to understand the functional aspects of PP2A and other phosphatases [12]. Other than Okadaic acid, calyculin A, microcystin, cantharidin, nodularm, fostriecin and tautomycin are able to inhibit PP2A activity at different IC50 values [48]. PubMed:23454242

Recently, a major indirect activation of PP2A by inhibiting CIP2A at both the transcriptional and translational levels through the drug bortezomib was shown in triple negative breast cancer cells [50]. PubMed:23454242

Endogenous CIP2A (cancerous inhibitor of PP2A) inhibits PP2Ac activity via interacting with c-Myc (Ser62) and stabilizes it from proteolytic degradation [49]. PubMed:23454242

Analyses of protein expression by using gel electrophore- sis and western blotting have shown not only a reduction of PP2A C expression levels but also a marked reduction of B55
, thus indicating that PP2A impairment is the result of combined effects of different subunits [60]. PubMed:22299660

Analyses of protein expression by using gel electrophore- sis and western blotting have shown not only a reduction of PP2A C expression levels but also a marked reduction of B55
, thus indicating that PP2A impairment is the result of combined effects of different subunits [60]. PubMed:22299660