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p(HGNC:CIP2A)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CIP2A
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

In-Edges 1

a(CHEBI:bortezomib) decreases p(HGNC:CIP2A) View Subject | View Object

Recently, a major indirect activation of PP2A by inhibiting CIP2A at both the transcriptional and translational levels through the drug bortezomib was shown in triple negative breast cancer cells [50]. PubMed:23454242

Appears in Networks:

Out-Edges 1

p(HGNC:CIP2A) decreases act(p(FPLX:PPP2C)) View Subject | View Object

Endogenous CIP2A (cancerous inhibitor of PP2A) inhibits PP2Ac activity via interacting with c-Myc (Ser62) and stabilizes it from proteolytic degradation [49]. PubMed:23454242

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.