bp(GO:"nicotine metabolic process")

Entity

Name

nicotine metabolic process

Namespace

go

Namespace Version

20190224

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/go-names.belns

In the body, nicotine is extensively metabolized and is susceptible to a significant first-pass effect during which 80–90% of it is metabolized by the liver. Also, the lung is able to metabolize nicotine, but to a much lesser degree [78, 79]. PubMed:28391535

In the body, nicotine is extensively metabolized and is susceptible to a significant first-pass effect during which 80–90% of it is metabolized by the liver. Also, the lung is able to metabolize nicotine, but to a much lesser degree [78, 79]. PubMed:28391535

In humans, about 70–80% of nicotine is converted to the primary metabolite (-)-cotinine, a lactam derivative (Fig. 2). PubMed:28391535

Lastly, S(-)-nornicotine is a minor metabolite of nicotine and, as mentioned previously, is considered a minor alkaloid of tobacco (Fig. 2) PubMed:28391535