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bp(GO:"neuron differentiation")

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Entity

Name
neuron differentiation
Namespace
go
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/73688d6dc24e309fca59a1340dc9ee971e9f3baa/external/go-names.belns

Appears in Networks 6

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

MMP-9 and MMP-2 Contribute to Neuronal Cell Death in iPSC Models of Frontotemporal Dementia with MAPT Mutations v1.0.0

Anti-aggregant tau mutant promotes neurogenesis v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 10

a(CHEBI:"calcium(2+)", loc(GO:intracellular)) regulates bp(GO:"neuron differentiation") View Subject | View Object

It was then recognized that Ca2+ flux directly through nAChR channels or indirectly via voltage-gated Ca2+ channels is relevant for nicotinic modulation of transmitter release, synaptic plasticity, as well as neuronal viability, differentiation, and migration. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

p(HGNC:CHRM1) association bp(GO:"neuron differentiation") View Subject | View Object

Among the mAChR family members, the M1 subtype makes up 50–60% of the total and is predominantly expressed in all major areas of the forebrain, including the hippocampus, cerebral cortex, corpus striatum, and thalamus[36-38]. M1 mAChR-knockout mice show a series of cognitive defi cits and impairments in long-term potentiation, indicating that the M1 subtype is physiologically linked to multiple functions such as synaptic plasticity, neuronal excitability, neuronal differentiation during early development, and learning and memory PubMed:24590577

Appears in Networks:

p(HGNC:MAPT, var("p.Ala152Thr")) causesNoChange bp(GO:"neuron differentiation") View Subject | View Object

Thus, both molecular and electrophysiological analyses suggest MAPT mutations do not affect early neuronal differentiation PubMed:27594586

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Frontotemporal Dementia

g(DBSNP:rs63751011) causesNoChange bp(GO:"neuron differentiation") View Subject | View Object

Thus, both molecular and electrophysiological analyses suggest MAPT mutations do not affect early neuronal differentiation PubMed:27594586

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Frontotemporal Dementia

p(HBP:"Tau isoform F (441 aa)", var("p.Ile277Pro"), var("p.Ile308Pro"), var("p.Lys280del")) increases bp(GO:"neuron differentiation") View Subject | View Object

In particular in the CA3 and DG regions almost 70% and in CA1 almost 50% of the new born cells got differentiated into NeuN positive neurons in the anti-aggregant TauRDΔKPP slices (Additional file 2: Figure S1A, bars 4, 8, 12).This reveals an increase in proliferation followed by an increase in neuronal differentiation in the anti-aggregant TauRDΔKPP slices PubMed:29202785

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
MeSH
CA3 Region, Hippocampal
MeSH
Dentate Gyrus

p(HBP:"Tau isoform F (441 aa)", var("p.Lys280del")) increases bp(GO:"neuron differentiation") View Subject | View Object

This also resulted in a 30% increase in the rate of differentiation in the CA1 region of the pro-aggregant TauRDΔK slices (Additional file 2: Fig. S1B, bars 2 and 4) PubMed:29202785

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal

p(MGI:Mapt) increases bp(GO:"neuron differentiation") View Subject | View Object

This suggests that the expression of anti-aggregant TauRDΔKPP is needed for the increased proliferation of newborn neurons, and since these new born neurons need endogenous mouse Tau for their migration, differentiation, and maturation, there is enhanced expression of endogenous mouse Tau PubMed:29202785

Appears in Networks:

a(HBP:"ID-8") decreases bp(GO:"neuron differentiation") View Subject | View Object

Here we present evidence that the indole compound ID-8 and a series of related molecules act to inhibit the neural specification of hESC through inhibition of DYRK1A. PubMed:28884684

Appears in Networks:

act(p(HGNC:DYRK1A), ma(kin)) positiveCorrelation bp(GO:"neuron differentiation") View Subject | View Object

Here we present evidence that the indole compound ID-8 and a series of related molecules act to inhibit the neural specification of hESC through inhibition of DYRK1A. PubMed:28884684

Appears in Networks:

p(FPLX:NFkappaB) association bp(GO:"neuron differentiation") View Subject | View Object

In the nervous system, NF-κB has been proposed to serve important function by acting as a transcription regulator: it has roles in inflammation, neuronal survival, differentiation, apoptosis, neurite outgrowth, and synaptic plasticity [5], which are impaired in the progression of various neurodegenerative diseases especially in AD. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Nervous System

Out-Edges 3

bp(GO:"neuron differentiation") association p(HGNC:CHRM1) View Subject | View Object

Among the mAChR family members, the M1 subtype makes up 50–60% of the total and is predominantly expressed in all major areas of the forebrain, including the hippocampus, cerebral cortex, corpus striatum, and thalamus[36-38]. M1 mAChR-knockout mice show a series of cognitive defi cits and impairments in long-term potentiation, indicating that the M1 subtype is physiologically linked to multiple functions such as synaptic plasticity, neuronal excitability, neuronal differentiation during early development, and learning and memory PubMed:24590577

Appears in Networks:

bp(GO:"neuron differentiation") positiveCorrelation act(p(HGNC:DYRK1A), ma(kin)) View Subject | View Object

Here we present evidence that the indole compound ID-8 and a series of related molecules act to inhibit the neural specification of hESC through inhibition of DYRK1A. PubMed:28884684

Appears in Networks:

bp(GO:"neuron differentiation") association p(FPLX:NFkappaB) View Subject | View Object

In the nervous system, NF-κB has been proposed to serve important function by acting as a transcription regulator: it has roles in inflammation, neuronal survival, differentiation, apoptosis, neurite outgrowth, and synaptic plasticity [5], which are impaired in the progression of various neurodegenerative diseases especially in AD. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Nervous System

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.