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bp(GO:"synaptic transmission, dopaminergic")

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Entity

Name
synaptic transmission, dopaminergic
Namespace
go
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/73688d6dc24e309fca59a1340dc9ee971e9f3baa/external/go-names.belns

Appears in Networks 5

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0

This file encodes the article Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer’s disease and schizophrenia by Choi et al, 2014

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

New insights into the role of microRNAs and long noncoding RNAs in most common neurodegenerative diseases v1.0.0

In-Edges 7

a(CHEBI:"glutamate(2-)", loc(MESH:"Dopaminergic Neurons")) increases bp(GO:"synaptic transmission, dopaminergic") View Subject | View Object

Other levels of regulation of dopaminergic transmission arise from alpha7 nAChRs located on cortical glutamatergic terminals; activation of these receptors increases glutamate release onto dopaminergic neurons in the VTA and, consequently, increases the their firing (344). PubMed:19126755

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Text Location
Review

act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") View Subject | View Object

In the basal ganglia, for instance, dopaminergic transmission is ultimately regulated by the activity of specific nAChR subtypes in different neurons and neuronal compartments (Fig. 5). Thus evidence exists that in the VTA,alpha6- andalpha4-containing nAChRs are mainly located on dopaminergic nerve terminals, whereas alpha7 nAChRs are primarily expressed on the soma of dopaminergic neurons (Fig. 5). PubMed:19126755

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MeSH
Basal Ganglia
Text Location
Review

act(p(HGNC:CHRNA7, loc(GO:"glutamatergic synapse"))) regulates bp(GO:"synaptic transmission, dopaminergic") View Subject | View Object

Other levels of regulation of dopaminergic transmission arise from alpha7 nAChRs located on cortical glutamatergic terminals; activation of these receptors increases glutamate release onto dopaminergic neurons in the VTA and, consequently, increases the their firing (344). PubMed:19126755

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Annotations
Text Location
Review

p(HGNC:CHRM4) regulates bp(GO:"synaptic transmission, dopaminergic") View Subject | View Object

The M4 receptor is highly expressed in the striatum, hippocampus, and neocortex,45,46 suggesting that this mAChR subtype is ideally located to modulate dopaminergic signaling. In support of this hypothesis, M4 KO mice exhibit a hyperdopaminergic phenotype that is resistant to mAChR agonist-induced attenuation of dopamine levels. PubMed:24511233

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a(MESH:"Cholinergic Neurons") increases bp(GO:"synaptic transmission, dopaminergic") View Subject | View Object

It has been postulated that the loss of cholinergic neurons and the consequent impairment in dopaminergic transmission could be the main factors underling AD-related psychiatric symptoms PubMed:26813123

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MeSH
CA3 Region, Hippocampal

path(MESH:"Parkinson Disease") negativeCorrelation bp(GO:"synaptic transmission, dopaminergic") View Subject | View Object

In PD, the main neuropathological feature is the progressive death of neurons in the substantia nigra pars compacta with resulting loss of dopaminergic innervation of the striatum. PubMed:14556719

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MeSH
Pars Compacta

p(HGNC:SNCA) association bp(GO:"synaptic transmission, dopaminergic") View Subject | View Object

This protein is commonly found in the presynaptic terminus and is a factor in the transmission of synaptic dopaminergic neurons. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

Out-Edges 2

bp(GO:"synaptic transmission, dopaminergic") negativeCorrelation path(MESH:"Parkinson Disease") View Subject | View Object

In PD, the main neuropathological feature is the progressive death of neurons in the substantia nigra pars compacta with resulting loss of dopaminergic innervation of the striatum. PubMed:14556719

Appears in Networks:
Annotations
MeSH
Pars Compacta

bp(GO:"synaptic transmission, dopaminergic") association p(HGNC:SNCA) View Subject | View Object

This protein is commonly found in the presynaptic terminus and is a factor in the transmission of synaptic dopaminergic neurons. PubMed:30663117

Appears in Networks:
Annotations
MeSH
Parkinson Disease

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.