1. Catalog
  2. Namespaces
  3. MeSH
  4. Basal Ganglia

Basal Ganglia

Name
Basal Ganglia
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 4

act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) regulates bp(GO:"synaptic transmission, dopaminergic") View Subject | View Object

In the basal ganglia, for instance, dopaminergic transmission is ultimately regulated by the activity of specific nAChR subtypes in different neurons and neuronal compartments (Fig. 5). Thus evidence exists that in the VTA,alpha6- andalpha4-containing nAChRs are mainly located on dopaminergic nerve terminals, whereas alpha7 nAChRs are primarily expressed on the soma of dopaminergic neurons (Fig. 5). PubMed:19126755

Appears in Networks:
Annotations
MeSH
Basal Ganglia
Text Location
Review

path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") View Subject | View Object

AD involves loss of cholinergic cells not only in the cortex but also in subcortical nuclei. Up to 50% loss of neurons and of ChAT activity has been reported at autopsy in the locus ceruleus of brains from patients with AD compared with brains from subjects without AD, whereas no change was observed for adrenergic brainstem nuclei (Strong et al., 1991). PubMed:19293145

Appears in Networks:
Annotations
MeSH
Basal Ganglia

path(MESH:"Alzheimer Disease") decreases act(p(HGNC:CHAT)) View Subject | View Object

AD involves loss of cholinergic cells not only in the cortex but also in subcortical nuclei. Up to 50% loss of neurons and of ChAT activity has been reported at autopsy in the locus ceruleus of brains from patients with AD compared with brains from subjects without AD, whereas no change was observed for adrenergic brainstem nuclei (Strong et al., 1991). PubMed:19293145

Appears in Networks:
Annotations
MeSH
Basal Ganglia

p(FPLX:CHRN) increases bp(GO:"dopamine secretion") View Subject | View Object

Indeed, presynaptic effects of nAChRs in regulating dopamine release in basal ganglia and prefrontal cortex likely participate in nicotine’s addictive and cognitive effects, respectively (Jasinska et al., 2014) PubMed:28445721

Appears in Networks:
Annotations
MeSH
Basal Ganglia
MeSH
Prefrontal Cortex

Showing 4 of 4 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.