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p(HGNC:DLG4)

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Entity

Name
DLG4
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 6

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers v1.0.0

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Tau in physiology and pathology v1.0.0

Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome v1.0.0

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse v1.0.0

In-Edges 16

a(HBP:"amyloid-beta oligomers") increases p(HGNC:DLG4) View Subject | View Object

Abetao exposure induced a translocation of tau into the PSD fraction (***p  0.0002, 2-tailed Student’s t test; control 20.12  1228 vs Abetao 29.74  1.748, N  12 independent culture). There was also an increase of PSD-95 (***p0.0006, 2-tailed Student’s t test; control 19.10  2.557 vs Abetao 33.3  2153, N  9 independent culture), GluA1 (**p  0.0078, 2-tailed Student’s t test; control 18.841.930 vs Abetao 26.221.475,N9 independent culture) and fyn (**p  0.0041, 2-tailed Student’s t test; control 19.42  1.337 vs Abetao 29.67  2.181, N  6 independent cultures; Fig. 6D). PubMed:24760868

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a(HBP:"amyloid-beta oligomers") decreases p(HGNC:DLG4, loc(GO:synapse)) View Subject | View Object

After Abetao treatment, synaptic activation did not trigger any increase in synaptic markers and in fact decreased synaptic actin (***p  0.0009, 2-tailed Student’s t test; Abetao 29.64  1.495, Abetao Bic/4-AP 18.56 2.030, N  7 independent cultures; Fig. 7C), PSD-95 (***p0.0007, 2-tailed Student’s t test; Abetao 33.37  2.153, Abetao Bic/4-AP 19.25 2.550, N  7 independent cultures) and tau levels (**p0.0014, 2-tailed Student’s t test; Abetao 29.74 1.748, Abetao Bic/4-AP 20.68 1.751, N  12 independent cultures). PubMed:24760868

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Results

bp(GO:"long-term synaptic potentiation") positiveCorrelation p(HGNC:DLG4, loc(GO:synapse)) View Subject | View Object

Therefore, during a long-lasting synaptic activation, we observed an increase in tau, fyn, actin, GluA1, and PSD-95 content in the PSD-positive fraction, which is consistent with the characteristic features of synaptic plasticity (Ehlers, 2003). PubMed:24760868

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Text Location
Results

p(HBP:"projection domain") association p(HGNC:DLG4) View Subject | View Object

In synapses, the projection domain of tau interacts with protein kinase Fyn (plays an important role during myelination [75]), postsynaptic density protein 95 (PSD-95) [76], and N-methyl-D-aspartate receptors (NMDAR). PubMed:26751493

Appears in Networks:

a(HBP:"projection domain") association p(HGNC:DLG4) View Subject | View Object

In synapses, the projection domain of tau interacts with protein kinase Fyn (plays an important role during myelination [75]), postsynaptic density protein 95 (PSD-95) [76], and N-methyl-D-aspartate receptors (NMDAR). PubMed:26751493

Appears in Networks:

complex(p(HGNC:DLG4), p(HGNC:FYN)) hasComponent p(HGNC:DLG4) View Subject | View Object

Appears in Networks:

a(PUBCHEM:9832404) decreases p(HGNC:DLG4) View Subject | View Object

The measurements showed similar patterns in both tested brain areas, with Adnp deficiency resulting in substantial decreases in spine density (male and female mice) and increases in PSD95-asymmetric shaft synapses (males only, as indicated by increased localization of PSD95 in dendritic shafts rather than spines), which were all rescued by NAP treatment. PubMed:30106381

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Annotations
MeSH
CA1 Region, Hippocampal
MeSH
Cerebral Cortex
MeSH
Pyramidal Cells
Gender
Male

a(PUBCHEM:9832404) decreases p(HGNC:DLG4) View Subject | View Object

This genotype- and sex-dependent pathology also extended to the cortex, with increased PSD95 shaft synapse density in Adnp+/– males compared with Adnp+/– females (P < 0.01), and was rescued by NAP treatment. PubMed:30106381

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
Gender
Male

a(PUBCHEM:9832404) causesNoChange p(HGNC:DLG4) View Subject | View Object

Importantly, in males, NAP treatment did not affect PSD95 shaft synapse density in either tested region (Supplemental Figures 3 and 4, insets). PubMed:30106381

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Annotations
Gender
Male

a(PUBCHEM:9832404) increases p(HGNC:DLG4) View Subject | View Object

Furthermore, NAP treatment increased PSD95 shaft synapse volume in both tested brain regions (Supplemental Figures 3 and 4, insets, P < 0.05). PubMed:30106381

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act(p(HGNC:ADNP)) association p(HGNC:DLG4) View Subject | View Object

In this respect, our previous data associated postsynaptic density protein 95 (PSD95, also known as DLG4) with ADNP/NAP activity PubMed:30664622

Appears in Networks:

bp(GO:"regulation of synaptic plasticity") association p(HGNC:DLG4) View Subject | View Object

Figure 3, Supplemental Figure 5 (younger age group), Supplemental Figure 6 (older age group), and Supplemental Tables 5 and 8 reveal an overall similar pattern of Adnp genotype–and NAP treatment–regulated human and mouse protein product interactions across ages with Akt1 (the mosaic mutations of which lead to the Proteus syndrome, characterized by the overgrowth of skin, connective tissue, brain, and other tissues; ref. 37) and discs large MAGUK scaffold protein 4 (Dlg4, also known as Psd95), a key regulator of synaptic plasticity (see above) that plays central roles associated with ADNP and NAP function. PubMed:30106381

Appears in Networks:

complex(p(HGNC:ADNP), p(HGNC:DLG4)) hasComponent p(HGNC:DLG4) View Subject | View Object

Appears in Networks:

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) View Subject | View Object

The measurements showed similar patterns in both tested brain areas, with Adnp deficiency resulting in substantial decreases in spine density (male and female mice) and increases in PSD95-asymmetric shaft synapses (males only, as indicated by increased localization of PSD95 in dendritic shafts rather than spines), which were all rescued by NAP treatment. PubMed:30106381

Appears in Networks:
Annotations
MeSH
CA1 Region, Hippocampal
MeSH
Cerebral Cortex
MeSH
Pyramidal Cells
Gender
Male

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases p(HGNC:DLG4) View Subject | View Object

This genotype- and sex-dependent pathology also extended to the cortex, with increased PSD95 shaft synapse density in Adnp+/– males compared with Adnp+/– females (P < 0.01), and was rescued by NAP treatment. PubMed:30106381

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
Gender
Male

act(a(PUBCHEM:9832404)) association p(HGNC:DLG4) View Subject | View Object

In this respect, our previous data associated postsynaptic density protein 95 (PSD95, also known as DLG4) with ADNP/NAP activity PubMed:30664622

Appears in Networks:

Out-Edges 8

p(HGNC:DLG4, loc(GO:synapse)) positiveCorrelation bp(GO:"long-term synaptic potentiation") View Subject | View Object

Therefore, during a long-lasting synaptic activation, we observed an increase in tau, fyn, actin, GluA1, and PSD-95 content in the PSD-positive fraction, which is consistent with the characteristic features of synaptic plasticity (Ehlers, 2003). PubMed:24760868

Appears in Networks:
Annotations
Text Location
Results

p(HGNC:DLG4) association p(HBP:"projection domain") View Subject | View Object

In synapses, the projection domain of tau interacts with protein kinase Fyn (plays an important role during myelination [75]), postsynaptic density protein 95 (PSD-95) [76], and N-methyl-D-aspartate receptors (NMDAR). PubMed:26751493

Appears in Networks:

p(HGNC:DLG4) association a(HBP:"projection domain") View Subject | View Object

In synapses, the projection domain of tau interacts with protein kinase Fyn (plays an important role during myelination [75]), postsynaptic density protein 95 (PSD-95) [76], and N-methyl-D-aspartate receptors (NMDAR). PubMed:26751493

Appears in Networks:

p(HGNC:DLG4) regulates act(p(HGNC:ADNP)) View Subject | View Object

Figure 3, Supplemental Figure 5 (younger age group), Supplemental Figure 6 (older age group), and Supplemental Tables 5 and 8 reveal an overall similar pattern of Adnp genotype–and NAP treatment–regulated human and mouse protein product interactions across ages with Akt1 (the mosaic mutations of which lead to the Proteus syndrome, characterized by the overgrowth of skin, connective tissue, brain, and other tissues; ref. 37) and discs large MAGUK scaffold protein 4 (Dlg4, also known as Psd95), a key regulator of synaptic plasticity (see above) that plays central roles associated with ADNP and NAP function. PubMed:30106381

Appears in Networks:

p(HGNC:DLG4) regulates act(a(PUBCHEM:9832404)) View Subject | View Object

Figure 3, Supplemental Figure 5 (younger age group), Supplemental Figure 6 (older age group), and Supplemental Tables 5 and 8 reveal an overall similar pattern of Adnp genotype–and NAP treatment–regulated human and mouse protein product interactions across ages with Akt1 (the mosaic mutations of which lead to the Proteus syndrome, characterized by the overgrowth of skin, connective tissue, brain, and other tissues; ref. 37) and discs large MAGUK scaffold protein 4 (Dlg4, also known as Psd95), a key regulator of synaptic plasticity (see above) that plays central roles associated with ADNP and NAP function. PubMed:30106381

Appears in Networks:

p(HGNC:DLG4) association bp(GO:"regulation of synaptic plasticity") View Subject | View Object

Figure 3, Supplemental Figure 5 (younger age group), Supplemental Figure 6 (older age group), and Supplemental Tables 5 and 8 reveal an overall similar pattern of Adnp genotype–and NAP treatment–regulated human and mouse protein product interactions across ages with Akt1 (the mosaic mutations of which lead to the Proteus syndrome, characterized by the overgrowth of skin, connective tissue, brain, and other tissues; ref. 37) and discs large MAGUK scaffold protein 4 (Dlg4, also known as Psd95), a key regulator of synaptic plasticity (see above) that plays central roles associated with ADNP and NAP function. PubMed:30106381

Appears in Networks:

p(HGNC:DLG4) association act(a(PUBCHEM:9832404)) View Subject | View Object

In this respect, our previous data associated postsynaptic density protein 95 (PSD95, also known as DLG4) with ADNP/NAP activity PubMed:30664622

Appears in Networks:

p(HGNC:DLG4) association act(p(HGNC:ADNP)) View Subject | View Object

In this respect, our previous data associated postsynaptic density protein 95 (PSD95, also known as DLG4) with ADNP/NAP activity PubMed:30664622

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.