p(HGNC:DLG4) regulates act(p(HGNC:ADNP))

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PubMed:30106381

Figure 3, Supplemental Figure 5 (younger age group), Supplemental Figure 6 (older age group), and Supplemental Tables 5 and 8 reveal an overall similar pattern of Adnp genotype–and NAP treatment–regulated human and mouse protein product interactions across ages with Akt1 (the mosaic mutations of which lead to the Proteus syndrome, characterized by the overgrowth of skin, connective tissue, brain, and other tissues; ref. 37) and discs large MAGUK scaffold protein 4 (Dlg4, also known as Psd95), a key regulator of synaptic plasticity (see above) that plays central roles associated with ADNP and NAP function.

Related Edges 8

• a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1))
• a(PUBCHEM:9832404) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4))
• bp(GO:"regulation of synaptic plasticity") association p(HGNC:DLG4)
• p(HGNC:DLG4) regulates act(a(PUBCHEM:9832404))
• p(HGNC:DLG4) association bp(GO:"regulation of synaptic plasticity")
• p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:DLG4))
• p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) regulates complex(p(HGNC:ADNP), p(HGNC:AKT1))
• p(HGNC:AKT1, var("?")) increases path(MESH:"Proteus Syndrome")

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