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r(HGNC:ADNP)

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Entity

Name
ADNP
Namespace
hgnc
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/efc856fb009a39e4d284269a6801f79ed3d3cf56/external/hgnc-names.belns

Appears in Networks 2

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice v1.0.0

In-Edges 3

a(PUBCHEM:9832404) increases r(HGNC:ADNP) View Subject | View Object

On the other hand, chronic treatment with an eight-amino-acid peptide snippet from ADNP (NAP), also known as davunetide, restored both Beclin1 and ADNP mRNA levels along with ADNP-LC3 interaction, thus providing neuroprotection while ameliorating schizophrenic-like behavioral and cognitive deficits in Map6+/- mice PubMed:30061532

Appears in Networks:
Annotations
MeSH
Schizophrenia

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) decreases r(HGNC:ADNP) View Subject | View Object

Originally, a reduction of 42% in the cortex, of 38% in cerebellum, and of 50% in hippocampus was observed in the levels of Adnp mRNA in Adnp+/− mice compared with Adnp intact mice PubMed:30008470

Appears in Networks:
Annotations
MeSH
Cerebellum
MeSH
Cerebral Cortex
MeSH
Hippocampus

path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) View Subject | View Object

As shown in Fig. 1, we found that this sub-chronic alcohol treatment increased Adnp mRNA levels in the dorsal hippocampus 24 h, but not 2 h after the last alcohol injection, in both male and female mice (one-way ANOVA; males: F(2,10) = 5.94, p < 0.05; post-hoc, p < 0.02. Females: F(2,10) = 5.22, p < 0.05, post hoc, p < 0.05) PubMed:30008470

Appears in Networks:
Annotations
MeSH
Hippocampus
Gender
Male
Gender
Female

Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.