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path(MESH:"Alcohol Drinking")

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Entity

Name
Alcohol Drinking
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mesh-names.belns

Appears in Networks 1

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice v1.0.0

In-Edges 6

composite(a(PUBCHEM:9832404), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) decreases path(MESH:"Alcohol Drinking") View Subject | View Object

Strikingly, NAP treatment reduced alcohol consumption in Adnp+/− mice, which did not differ from Adnp+/+ controls. PubMed:30008470

Appears in Networks:
Annotations
Gender
Female

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") View Subject | View Object

Importantly, Adnp+/− females showed higher alcohol consumption and preference, compared to female Adnp+/+ controls, whereas no difference was observed in males. PubMed:30008470

Appears in Networks:
Annotations
Gender
Female

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange path(MESH:"Alcohol Drinking") View Subject | View Object

Importantly, Adnp+/− females showed higher alcohol consumption and preference, compared to female Adnp+/+ controls, whereas no difference was observed in males. PubMed:30008470

Appears in Networks:
Annotations
Gender
Male

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") View Subject | View Object

As shown in Fig. 3e, f, we found no difference between genotypes in saccharin or quinine intake, suggesting that the effect of Adnp deficiency is specific to alcohol, and does not apply to sweet reinforcers or bitter-taste solutions PubMed:30008470

Appears in Networks:
Annotations
Gender
Female

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) increases path(MESH:"Alcohol Drinking") View Subject | View Object

As Fig. 4b depicts, over the first 2 weeks of drinking (no treatment or intranasal vehicle treatment) Adnp+/− females showed higher alcohol consumption as compared to their Adnp+/+ littermates, replicating our results above. PubMed:30008470

Appears in Networks:
Annotations
Gender
Female

g(HGNC:ADNP) negativeCorrelation path(MESH:"Alcohol Drinking") View Subject | View Object

Together, our results indicate that reduced Adnp gene dosage leads to increased alcohol intake in female mice. PubMed:30008470

Appears in Networks:
Annotations
Gender
Female

Out-Edges 9

path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) View Subject | View Object

In addition, Adnp expression was increased at the 24 h time point in the NAc of female, but not male mouse (one-way ANOVA; females: F(2,9) = 10.87, p < 0.005; post hoc: p < 0.005; males: p > 0.05). PubMed:30008470

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens
Gender
Female

path(MESH:"Alcohol Drinking") increases r(HGNC:ADNP) View Subject | View Object

As shown in Fig. 1, we found that this sub-chronic alcohol treatment increased Adnp mRNA levels in the dorsal hippocampus 24 h, but not 2 h after the last alcohol injection, in both male and female mice (one-way ANOVA; males: F(2,10) = 5.94, p < 0.05; post-hoc, p < 0.02. Females: F(2,10) = 5.22, p < 0.05, post hoc, p < 0.05) PubMed:30008470

Appears in Networks:
Annotations
MeSH
Hippocampus
Gender
Male
Gender
Female

path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) View Subject | View Object

In addition, Adnp expression was increased at the 24 h time point in the NAc of female, but not male mouse (one-way ANOVA; females: F(2,9) = 10.87, p < 0.005; post hoc: p < 0.005; males: p > 0.05). PubMed:30008470

Appears in Networks:
Annotations
MeSH
Nucleus Accumbens
Gender
Male

path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) View Subject | View Object

We found no changes in the expression of Adnp in the VTA (p’s > 0.05). PubMed:30008470

Appears in Networks:
Annotations
MeSH
Ventral Tegmental Area
Gender
Male
Gender
Female

path(MESH:"Alcohol Drinking") increases p(HGNC:ADNP) View Subject | View Object

We found that among male mice, Adnp mRNA levels were increased in the dorsal hippocampus after a 24 h alcohol drinking session, but the level returned to baseline (water-drinking controls) after 24 h of withdrawal (Fig. 2b; one-way ANOVA: F(2,13) = 5.32, p < 0.05, post hoc comparisons, p’s < 0.05) PubMed:30008470

Appears in Networks:
Annotations
MeSH
Hippocampus
Gender
Male

path(MESH:"Alcohol Drinking") decreases p(HGNC:ADNP) View Subject | View Object

However, in female mice, the expression of Adnp was reduced after a 24-h alcohol-drinking session, and this reduction persisted after a 24-h withdrawal (Fig. 2c; one-way ANOVA: F(2,13) = 7.53, p < 0.01, post hoc comparisons, p’s < 0.05). PubMed:30008470

Appears in Networks:
Annotations
MeSH
Hippocampus
Gender
Female

path(MESH:"Alcohol Drinking") causesNoChange p(HGNC:ADNP) View Subject | View Object

No changes in Adnp levels were detected in the VTA or NAc (p’s > 0.05). PubMed:30008470

Appears in Networks:
Annotations
MeSH
Ventral Tegmental Area
Gender
Male
Gender
Female

path(MESH:"Alcohol Drinking") negativeCorrelation g(HGNC:ADNP) View Subject | View Object

Together, our results indicate that reduced Adnp gene dosage leads to increased alcohol intake in female mice. PubMed:30008470

Appears in Networks:
Annotations
Gender
Female

path(MESH:"Alcohol Drinking") decreases p(HGNC:TFAP2B) View Subject | View Object

For example, one of these common genes was transcription factor AP2 beta (TFAP2b), which is downregulated by chronic alcohol exposure [41]. This gene had a 3.8-fold increased expression in female Adnp+/− mice, and in contrast, a five-fold decreased expression in male Adnp+/− mice, as compared to sex-matched Adnp+/+controls. PubMed:30008470

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.