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Appears in Networks 3

In-Edges 2

Out-Edges 3

g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") View Subject | View Object

However, a significant risk of AD development is related to certain genetic changes: the sporadic form of AD can be associated with the presence of apolipoprotein E (APOE) ε4 genotype (Holtzman et al. 2012; Spinney 2014), whereas the familial Alzheimer’s disease (FAD) can be linked to mutations in presenilin1 (PS1), presenilin2 (PS2), and amyloid precursor protein (APP) genes (reviewed by Hardy and Gwinn-Hardy 1998). PubMed:29196815

g(HGNC:PSEN2, var("?")) association path(MESH:"Alzheimer Disease") View Subject | View Object

When characterized by autosomal dominant inheritance, EOAD is related to mutations in the presenilin 1 (PSEN1), presenilin 2 (PSEN2) or amyloid precursor protein (APP) genes. PubMed:26195256

g(HGNC:PSEN2, var("?")) increases path(MESH:"Alzheimer Disease") View Subject | View Object

In addition, several other gene mutations have been discovered such as Presenilin-1 and Presenilin-2 mutations, which increase the risk for developing AD. 38 PubMed:30444369


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.