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Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau 1.0.0

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Provenance

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:23:01.205319
Authors
Sandra Spalek
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
57
Number Edges
116
Number Components
1
Network Density
0.0363408521303258
Average Degree
2.03508771929825
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0 38%
Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0 33%
Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular Aggregation v1.0.0 18%
Tau Modifications v1.9.5 18%
Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport. v1.0.0 13%
Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers v1.0.0 12%
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer’s disease brain v1.0.1 12%
Alzheimer's disease pathological lesions activate the spleen tyrosine kinase. v1.0.0 12%
Tau in physiology and pathology v1.0.0 11%
Tau Biochemistry v1.2.5 11%

Sample Edges

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("?")) View Subject | View Object

a(HBP:HBP00166) increases complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) View Subject | View Object

The analysis reveals that the proline-rich regions P1–P2 and the four pseudo-repeats contribute to the Tau/F-actin interaction PubMed:29215007

Annotations
Confidence
High

a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) View Subject | View Object

The combined data—(i) competition of binding of Tau to F-actin by cofilin, which interacts with actin’s hydrophobic pocket, and (ii) residue-specific PRE effects in the repeat domain of Tau by preferential MTSSL-labeling of C374 in proximity to the hydrophobic pocket—suggest that Tau binds to the solvent-exposed hydrophobic pocket that is located between subdomains 1 and 3 of actin PubMed:29215007

Annotations
Confidence
Medium

a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) View Subject | View Object

The combined data—(i) competition of binding of Tau to F-actin by cofilin, which interacts with actin’s hydrophobic pocket, and (ii) residue-specific PRE effects in the repeat domain of Tau by preferential MTSSL-labeling of C374 in proximity to the hydrophobic pocket—suggest that Tau binds to the solvent-exposed hydrophobic pocket that is located between subdomains 1 and 3 of actin PubMed:29215007

Annotations
Confidence
Medium

a(HBP:HBP00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1)) View Subject | View Object

The combined data—(i) competition of binding of Tau to F-actin by cofilin, which interacts with actin’s hydrophobic pocket, and (ii) residue-specific PRE effects in the repeat domain of Tau by preferential MTSSL-labeling of C374 in proximity to the hydrophobic pocket—suggest that Tau binds to the solvent-exposed hydrophobic pocket that is located between subdomains 1 and 3 of actin PubMed:29215007

Annotations
Confidence
Medium

Sample Nodes

path(MESH:"Alzheimer Disease")

In-Edges: 536 | Out-Edges: 704 | Classes: 5 | Explore Neighborhood | Download JSON

p(HGNC:MAPT)

In-Edges: 477 | Out-Edges: 480 | Classes: 11 | Children: 27 | Explore Neighborhood | Download JSON

a(MESH:Caspases)

In-Edges: 0 | Out-Edges: 7 | Explore Neighborhood | Download JSON

p(HGNC:MAPT, var("?"))

In-Edges: 9 | Out-Edges: 10 | Explore Neighborhood | Download JSON

a(MESH:Actins)

In-Edges: 4 | Out-Edges: 0 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.