a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:CFL1))

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PubMed:29215007

The combined data—(i) competition of binding of Tau to F-actin by cofilin, which interacts with actin’s hydrophobic pocket, and (ii) residue-specific PRE effects in the repeat domain of Tau by preferential MTSSL-labeling of C374 in proximity to the hydrophobic pocket—suggest that Tau binds to the solvent-exposed hydrophobic pocket that is located between subdomains 1 and 3 of actin

Related Edges 5

• a(HBP:HBP00169) positiveCorrelation complex(a(GO:"filamentous actin"), p(HGNC:MAPT))
• a(HBP:HBP00169) positiveCorrelation complex(a(MESH:Actins), p(HGNC:CFL1))
• complex(a(GO:"filamentous actin"), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169)
• complex(a(GO:"filamentous actin"), p(HGNC:MAPT)) positiveCorrelation a(HBP:HBP00169)
• complex(a(MESH:Actins), p(HGNC:CFL1)) positiveCorrelation a(HBP:HBP00169)

Confidence

Medium

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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