1. Catalog
  2. Nodes
  3. a(MESH:Actins)

a(MESH:Actins)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Actins
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 4

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau v1.0.0

Activity-dependent tau protein translocation to excitatory synapse is disrupted by exposure to amyloid-beta oligomers v1.0.0

Tau in physiology and pathology v1.0.0

In-Edges 4

p(HGNC:PRKN) regulates act(a(MESH:Actins)) View Subject | View Object

Yet, it is possible that the ligase regulates actin activity by ubiquitinating an actin-associated protein, which in turn affects the function of actin and thereby influences the movement of synaptic vesicles PubMed:14556719

Appears in Networks:

complex(a(MESH:Actins), p(HGNC:CFL1)) hasComponent a(MESH:Actins) View Subject | View Object

Appears in Networks:

a(HBP:"amyloid-beta oligomers") decreases a(MESH:Actins, loc(GO:synapse)) View Subject | View Object

After Abetao treatment, synaptic activation did not trigger any increase in synaptic markers and in fact decreased synaptic actin (***p  0.0009, 2-tailed Student’s t test; Abetao 29.64  1.495, Abetao Bic/4-AP 18.56 2.030, N  7 independent cultures; Fig. 7C), PSD-95 (***p0.0007, 2-tailed Student’s t test; Abetao 33.37  2.153, Abetao Bic/4-AP 19.25 2.550, N  7 independent cultures) and tau levels (**p0.0014, 2-tailed Student’s t test; Abetao 29.74 1.748, Abetao Bic/4-AP 20.68 1.751, N  12 independent cultures). PubMed:24760868

Appears in Networks:
Annotations
Text Location
Results

complex(a(MESH:Actins), p(HGNC:MAPT)) hasComponent a(MESH:Actins) View Subject | View Object

Appears in Networks:

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.