a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016)

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PubMed:28803412

Epigallocatechin-3-gallate (EGCG), a small molecule that been shown to inhibit the aggregation of several amyloidogenic proteins such as a-syn, amyloid-beta and huntingtin [9, 37, 38, 105] binds to unfolded native amyloid-beta and a-syn and promotes the formation of nontoxic oligomers that do not convert into amyloid fibrils [37].

Related Edges 2

• a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018)
• a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00017)

Confidence

High

MeSH

Brain

MeSH

Cerebrospinal Fluid

MeSH

Serum

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