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Nicotinic α4β2 acetylcholine receptors and cognitive function in Parkinson's disease 1.0.0

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charles.hoyt@scai.fraunhofer.de at 2019-02-27 16:16:45.876209
Authors
Lingling Xu
Contact
charles.hoyt@scai.fraunhofer.de
License
CC BY 4.0
Copyright
Copyright © 2018 Fraunhofer Institute SCAI, All rights reserved.
Number Nodes
9
Number Edges
21
Number Components
1
Network Density
0.291666666666667
Average Degree
2.33333333333333
Number Citations
1
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0 33%
Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0 22%
Tau in physiology and pathology v1.0.0 11%
Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0 11%
Nicotinic Receptor Abnormalities of Alzheimer’s Disease: Therapeutic Implications v1.0.0 11%
The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0 11%
The Biology of Proteostasis in Aging and Disease v1.0.0 11%
Alpha-synuclein oligomers: a new hope v1.0.0 11%
Structural and functional properties of prefibrillar α-synuclein oligomers v1.0.0 11%
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0 11%

Sample Edges

a(MESH:"Corpus Striatum") association complex(HBP:"alpha-4 beta-2 nAChR") View Subject | View Object

The most intense accumulation of 5-I-A-85380 was detected in both thalami, pons and midbrain, and both nuclei lentiformes PubMed:24762290

a(MESH:"Parietal Lobe") association complex(HBP:"alpha-4 beta-2 nAChR") View Subject | View Object

We found high correlation coefficients for four brain regions (right superior parietal lobule, left thalamus, right pos- terior subcortical region, and left posterior subcor- tical region) and two CERAD subtests (Word List Intrusions and Boston Naming Test), some of them were statistically significant. PubMed:24762290

a(MESH:"White Matter") positiveCorrelation complex(HBP:"alpha-4 beta-2 nAChR") View Subject | View Object

The right cerebellar white matter revealed a sig- nificantly higher 5-I-A-85380 uptake than the left cerebellar white matter. PubMed:24762290

a(MESH:Mesencephalon) association complex(HBP:"alpha-4 beta-2 nAChR") View Subject | View Object

The most intense accumulation of 5-I-A-85380 was detected in both thalami, pons and midbrain, and both nuclei lentiformes PubMed:24762290

a(MESH:Pons) association complex(HBP:"alpha-4 beta-2 nAChR") View Subject | View Object

The most intense accumulation of 5-I-A-85380 was detected in both thalami, pons and midbrain, and both nuclei lentiformes PubMed:24762290

Sample Nodes

path(MESH:"Parkinson Disease")

In-Edges: 68 | Out-Edges: 53 | Explore Neighborhood | Download JSON

path(MESH:Memory)

In-Edges: 6 | Out-Edges: 3 | Explore Neighborhood | Download JSON

a(MESH:"Corpus Striatum")

In-Edges: 4 | Out-Edges: 4 | Explore Neighborhood | Download JSON

a(MESH:Thalamus)

In-Edges: 3 | Out-Edges: 3 | Explore Neighborhood | Download JSON

a(MESH:"White Matter")

In-Edges: 3 | Out-Edges: 3 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.