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complex(p(HGNC:MAPT), p(HGNC:MAPT))

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Components

Appears in Networks 2

Tau oligomers and tau toxicity in neurodegenerative disease v1.0.0

Tau oligomers and tau toxicity in neurodegenerative disease by Ward et al., 2012

Inert and seed-competent tau monomers suggest structural origins of aggregation v1.0.0

In-Edges 1

p(HGNC:MAPT, var("p.Cys299Ala"), var("p.Cys322Ala")) decreases complex(p(HGNC:MAPT), p(HGNC:MAPT)) View Subject | View Object

Thus, for our initial studies we engineered and purified full-length (FL) tau monomer that lacks any internal cysteines due to alanine substitu- tions (C299A and C322A), termed tau (2A). FL tau (2A) cannot self-associate based on disulfide link- ages, which helped prevent the formation of cryptic dimers that could have confounded our studies. PubMed:29988016

Appears in Networks:

Out-Edges 2

complex(p(HGNC:MAPT), p(HGNC:MAPT)) hasComponent p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

complex(p(HGNC:MAPT), p(HGNC:MAPT)) increases a(HBP:"Tau oligomers") View Subject | View Object

Time-course aggregation analysis revealed that dimerization precedes tau oligomerization which, in turn, is an earlier event than the formation of full-length filaments PubMed:22817713

Appears in Networks:
Annotations
Confidence
High
MeSH
Intracellular Space

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.