p(HGNC:IDE) decreases a(CHEBI:"amyloid-beta")

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PubMed:28019679

The combined effect of the increased IDE production and phagocytic Abeta clearance reduced the cerebral Abeta load substantially, even at late life. Since immunohistochemistry found NLRP3 exclusively expressed in microglial cells, it has been concluded that the observed changes were entirely due to NLRP3 inflammasome modulation in these cells

Related Edges 1

• p(HGNC:IDE) regulates complex(GO:"NLRP3 inflammasome complex")

Confidence

Medium

MeSH

Neurons

NeuroMMSigDB

Amyloidogenic subgraph

NeuroMMSigDB

Insulin signal transduction

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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