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Blood-Brain Barrier

Name
Blood-Brain Barrier
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:rifampicin) increases act(p(FPLX:"GPIb_IX_V")) View Subject | View Object

The antibiotic rifampicin likewise promoted Aβ42 clearance by induc- ing BBB-localized LRP1 and P glycoprotein 1 (REFS273,292) . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Blood-Brain Barrier

a(CHEBI:rifampicin) increases act(p(HGNC:LRP1)) View Subject | View Object

The antibiotic rifampicin likewise promoted Aβ42 clearance by induc- ing BBB-localized LRP1 and P glycoprotein 1 (REFS273,292) . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Blood-Brain Barrier

a(CHEBI:calcitriol) decreases p(HGNC:AGER) View Subject | View Object

1,25(OH)2D3, the active form of vitamin D, plays a key role in enhancing transport of Aβ1–40 from the brain to the blood by reducing RAGE levels at the BBB, and also in contributing to periphery clearance by increasing levels of LRP1 both in vivo and in vitro (Guo et al. 2016b) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Blood-Brain Barrier

a(CHEBI:oleocanthal) increases p(HGNC:ABCB1) View Subject | View Object

Oleocanthal, a special component of extra-virgin olive oil, increases cerebral clearance of Aβ across the BBB by enhancing the expression of important efflux transport proteins at the BBB containing LRP1 and P-gp, and activating the APOE-dependent Aβ clearance pathway in mice brains (Qosa et al. 2015) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Blood-Brain Barrier

p(HGNC:SLC2A1) increases p(HGNC:LRP1) View Subject | View Object

GLUT1, glucose transporter expressed in the BBB, regulates LRP1-dependent Aβ clearance via increasing the expression of LRP1 PubMed:29626319

Appears in Networks:
Annotations
MeSH
Blood-Brain Barrier

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.