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  3. PubMed:26472524

PubMed: 26472524

Title
Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine.
Journal
International review of neurobiology
Volume
124
Issue
None
Pages
3-19
Date
2015-01-01
Authors
Dani JA

Evidence c5a92fc3b7
JSON

While nAChR activity causes depolarization, the divalent cation permeability plays an impor- tant physiological role by supplying ionic signals, including calcium (Bertrand, Galzi, Devillers-Thiery, Bertrand, & Changeux, 1993b; Dani & Bertrand, 2007; Decker & Dani, 1990; Gray, Rajan, Radcliffe, Yakehiro, & Dani, 1996; McGehee, Heath, Gelber, Devay, & Role, 1995; Vernino et al., 1992).

tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") View Subject | View Object

Appears in Networks:

tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) increases bp(GO:"membrane depolarization") View Subject | View Object

Appears in Networks:

act(p(FPLX:CHRN)) increases bp(GO:"membrane depolarization") View Subject | View Object

Appears in Networks:

Evidence 0a56b67b2e
JSON

Although calcium modulation can act intracellularly, nAChRs also are allosterically modulated by extracellular calcium, leading to dramatic changes in the channel opening probability (Amador & Dani, 1995; Mulle, Lena, & Changeux, 1992; Vernino et al., 1992).

a(CHEBI:"calcium(2+)") regulates act(p(FPLX:CHRN)) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Extracellular Space

Evidence 246b9644dc
JSON

Those that contain β 2 ( β 2 * ) commonly have high affinity for nicotine, desensitize to low agonist con- centrations, have relatively slow kinetics, and do not bind α -bungarotoxin.

a(CHEBI:nicotine) increases act(p(HGNC:CHRNA7)) View Subject | View Object

Appears in Networks:

Evidence cffcc58ce1
JSON

Simultaneously, activity of postsynaptic (and somatic) α 4 β 2 * nAChRs depolarizes DA neurons leading to enhanced action potential firing (Zhang et al., 2009).

bp(GO:"depolarization of postsynaptic membrane") increases bp(GO:"regulation of action potential firing rate") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

act(p(HBP:"alpha-4 beta-2 nAChR")) increases bp(GO:"depolarization of postsynaptic membrane") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
dopaminergic neuron
MeSH
Post-Synaptic Density

Evidence 056fb5c70a
JSON

All the mammalian neuronal nAChR subtypes do share the general func- tional property of being permeable to small monovalent and divalent cations. The main conducting species under biological conditions are Na+, K+, and Ca2+.

p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases tloc(a(CHEBI:"sodium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases tloc(a(CHEBI:"potassium(1+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases tloc(a(CHEBI:"calcium(2+)"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) View Subject | View Object

Appears in Networks:

Evidence 13e7fe6895
JSON

Mammalian nAChRs are cation selective, being permeable to small monovalent and divalent cations that can fit through the narrowest hydro- philic region of the open pore (Albuquerque et al., 2009; Dani, 1989; Dani & Bertrand, 2007; Dani & Eisenman, 1987).

p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Monovalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Extracellular Space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) increases tloc(a(MESH:"Cations, Divalent"), fromLoc(MESH:"Intracellular Space"), toLoc(MESH:"Extracellular Space")) View Subject | View Object

Appears in Networks:

Evidence 2cc87a2d2b
JSON

Although many areas of the brain participate, nicotinic receptors of the midbrain dopa- mine (DA) area are particularly important during the initiation of the addic- tion process (Dani et al., 2014; De Biasi & Dani, 2011).

act(p(FPLX:CHRN)) increases path(MESH:"Behavior, Addictive") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron

Evidence 060d593814
JSON

Activation of the presynaptic nAChRs (commonly but not exclusively α 7 * nAChRs) enhances the release of glutamate (Dani et al., 2000; Mansvelder & McGehee, 2000, 2002).

act(p(FPLX:CHRN)) increases sec(a(CHEBI:"glutamate(2-)")) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Presynaptic Terminals

Evidence d13d5fbe7e
JSON

For example, those that contain the α 7 subunit ( α 7 * ) as a homomeric or heteromeric receptor most commonly also have accompany- ing characteristics. They bind α -bungarotoxin, have relatively low affinity for nicotine and have relatively fast kinetics.

p(HBP:"alpha-7-containing nAChR") increases act(p(HGNC:CHRNA7)) View Subject | View Object

Appears in Networks:

Evidence 9b7ecd29dd
JSON

This depolarization and firing of the DA neurons helps to relieve the divalent cation block of NMDA receptors and, thus, enables the NMDA receptors to participate in long-term synaptic potentiation of glutamatergic afferents onto midbrain dopamine neurons.

act(p(MESH:"Receptors, N-Methyl-D-Aspartate")) increases bp(GO:"long-term synaptic potentiation") View Subject | View Object

Appears in Networks:
Annotations
Cell Ontology (CL)
glutamatergic neuron

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