1. Catalog
  2. Citations
  3. PubMed:29221819

PubMed: 29221819

Title
Cerebellar alterations in a model of Down syndrome: The role of the Dyrk1A gene.
Journal
Neurobiology of disease
Volume
110
Issue
None
Pages
206-217
Date
2018-02-01
Authors
Berciano MT | García-Cerro S | Lafarga M | Lantigua S | Martínez-Cué C | Padro D | Ramos-Cabrer P | Rueda N | Vidal V

Evidence 2bcf1a8917
JSON

Normalizing the gene dosage of Dyrk1A in the TS mouse rescued the density of senescent cells in the cingulate cortex, hippocampus and septum, prevented cholinergic neuron degeneration, and reduced App expression in the hippocampus, Aß load in the cortex and hippocampus, the expression of phosphorylated tau at the Ser202 residue in the hippocampus and cerebellum and the levels of total tau in the cortex, hippocampus and cerebellum.

a(CHEBI:"amyloid-beta") negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

act(a(HBP:"cholinergic neuron")) positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

bp(GO:"cellular senescence") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Mapt) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebellum
Uberon
cerebral cortex
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation bp(GO:"cellular senescence") View Subject | View Object

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation act(a(HBP:"cholinergic neuron")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cingulate cortex
Uberon
hippocampal formation
Uberon
septum
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation p(MGI:App) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation a(CHEBI:"amyloid-beta") View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebral cortex
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebellum
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation p(MGI:Mapt) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebellum
Uberon
cerebral cortex
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:App) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Mapt, pmod(Ph, Ser, 202)) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
Uberon
cerebellum
Uberon
hippocampal formation
MeSH
Alzheimer Disease
MeSH
Down Syndrome

Evidence 39ddc8fb8a
JSON

The normalization of the Dyrk1A gene dosage did not rescue the reduced cerebellar volume but increased the size of the granular and molecular layers, the densities of granular and Purkinje cells, and dendritic arborization.

a(HBP:"Purkinje cell layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(HBP:"granular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(HBP:"molecular layer of cerebellar cortex") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

bp(GO:"dendrite arborization") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation a(HBP:"granular layer of cerebellar cortex") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation a(HBP:"molecular layer of cerebellar cortex") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation a(HBP:"Purkinje cell layer of cerebellar cortex") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation bp(GO:"dendrite arborization") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.