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bp(GO:"actin cytoskeleton reorganization")

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Entity

Name
actin cytoskeleton reorganization
Namespace
go
Namespace Version
20190207
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/a5b84013a08880975ca84f40999e4404b14a97e2/external/go-names.belns

Appears in Networks 2

Tau in physiology and pathology v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 6

complex(a(GO:microtubule), p(HGNC:MAPT)) increases bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

Tau thereby stabilizes microtubules, promotes microtubule assembly and, in particular, regulates the dynamic instability of microtubules that allows reorganization of the cytoskeleton. PubMed:26631930

Appears in Networks:

a(CHEBI:heme) positiveCorrelation bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

We quantified these changes by automatic image analysis and found that heme-induced cytoskeleton rearrangement led to a significant increase in cell area and perimeter, as well as a decrease in circularity (form factor) (Fig. 4d,e and Supplementary Fig. 3b–d), indicating that the heme-induced defective phagocytic response was likely tied to cytoskeleton rearrangements. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:quinine) negativeCorrelation bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

Quinine pretreatment protected RAW264.7 macrophages (Fig. 8b and Supplementary Fig. 8c,d) and human macrophages (Fig. 8c) from heme-induced inhibition of phagocytosis and actin cytoskeleton changes (Supplementary Fig. 8e,f) compared with DMSO-treated cells. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:Phagocytosis) negativeCorrelation bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

We quantified these changes by automatic image analysis and found that heme-induced cytoskeleton rearrangement led to a significant increase in cell area and perimeter, as well as a decrease in circularity (form factor) (Fig. 4d,e and Supplementary Fig. 3b–d), indicating that the heme-induced defective phagocytic response was likely tied to cytoskeleton rearrangements. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:Phagocytosis) negativeCorrelation bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

Together, these data indicate that heme induces extensive actin cytoskeleton alterations, which results in defective phagocytosis and inflammatory cell migration. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

p(MGI:Dock8) positiveCorrelation bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

Our finding that DOCK8 is necessary for the cytoskeleton changes and disruption of bacterial phagocytosis by heme is consistent with recent studies showing that DOCK8 regulates dendritic cell migration via Cdc42 (refs. 37,44). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Discussion

Out-Edges 5

bp(GO:"actin cytoskeleton reorganization") positiveCorrelation a(CHEBI:heme) View Subject | View Object

We quantified these changes by automatic image analysis and found that heme-induced cytoskeleton rearrangement led to a significant increase in cell area and perimeter, as well as a decrease in circularity (form factor) (Fig. 4d,e and Supplementary Fig. 3b–d), indicating that the heme-induced defective phagocytic response was likely tied to cytoskeleton rearrangements. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(GO:"actin cytoskeleton reorganization") negativeCorrelation bp(MESH:Phagocytosis) View Subject | View Object

We quantified these changes by automatic image analysis and found that heme-induced cytoskeleton rearrangement led to a significant increase in cell area and perimeter, as well as a decrease in circularity (form factor) (Fig. 4d,e and Supplementary Fig. 3b–d), indicating that the heme-induced defective phagocytic response was likely tied to cytoskeleton rearrangements. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(GO:"actin cytoskeleton reorganization") negativeCorrelation bp(MESH:Phagocytosis) View Subject | View Object

Together, these data indicate that heme induces extensive actin cytoskeleton alterations, which results in defective phagocytosis and inflammatory cell migration. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(GO:"actin cytoskeleton reorganization") negativeCorrelation a(CHEBI:quinine) View Subject | View Object

Quinine pretreatment protected RAW264.7 macrophages (Fig. 8b and Supplementary Fig. 8c,d) and human macrophages (Fig. 8c) from heme-induced inhibition of phagocytosis and actin cytoskeleton changes (Supplementary Fig. 8e,f) compared with DMSO-treated cells. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(GO:"actin cytoskeleton reorganization") positiveCorrelation p(MGI:Dock8) View Subject | View Object

Our finding that DOCK8 is necessary for the cytoskeleton changes and disruption of bacterial phagocytosis by heme is consistent with recent studies showing that DOCK8 regulates dendritic cell migration via Cdc42 (refs. 37,44). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Discussion

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.