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p(HGNC:ESR1)

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Entity

Name
ESR1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease v1.0.0

In-Edges 5

p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) association p(HGNC:ESR1) View Subject | View Object

To confirm the localization of ERα in NFTs, double fluorescence staining with antibodies to ERα and hyperphosphorylated tau (PHF-1) revealed that ERα -positive NFTs were also positive for PHF-1 (Fig. 2A–F). PubMed:26837465

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) View Subject | View Object

In the hippocampal and cortical tissues of all AD cases examined, neuronal staining for ERα was a prominent finding, both with a weak cytoplasmic stain, but often specifically with a fibrillar appearance suggesting ERα was in neurofibrillary tangles (Fig. 1A), also shown at a higher magnification (Fig. 1B). PubMed:26837465

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

complex(GO:"neurofibrillary tangle") association p(HGNC:ESR1) View Subject | View Object

To confirm the localization of ERα in NFTs, double fluorescence staining with antibodies to ERα and hyperphosphorylated tau (PHF-1) revealed that ERα -positive NFTs were also positive for PHF-1 (Fig. 2A–F). PubMed:26837465

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

complex(p(HGNC:ESR1), p(HGNC:MAPT)) hasComponent p(HGNC:ESR1) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT) decreases act(p(HGNC:ESR1), ma(tscript)) View Subject | View Object

Tau overexpression inhibits transcriptional activity of ERα. PubMed:26837465

Appears in Networks:
Annotations
Confidence
High
MeSH
Cerebral Cortex
MeSH
Hippocampus

Out-Edges 3

p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") View Subject | View Object

In the hippocampal and cortical tissues of all AD cases examined, neuronal staining for ERα was a prominent finding, both with a weak cytoplasmic stain, but often specifically with a fibrillar appearance suggesting ERα was in neurofibrillary tangles (Fig. 1A), also shown at a higher magnification (Fig. 1B). PubMed:26837465

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

p(HGNC:ESR1) association complex(GO:"neurofibrillary tangle") View Subject | View Object

To confirm the localization of ERα in NFTs, double fluorescence staining with antibodies to ERα and hyperphosphorylated tau (PHF-1) revealed that ERα -positive NFTs were also positive for PHF-1 (Fig. 2A–F). PubMed:26837465

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

p(HGNC:ESR1) association p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

To confirm the localization of ERα in NFTs, double fluorescence staining with antibodies to ERα and hyperphosphorylated tau (PHF-1) revealed that ERα -positive NFTs were also positive for PHF-1 (Fig. 2A–F). PubMed:26837465

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Cerebral Cortex
MeSH
Hippocampus

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.