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bp(MESH:"Pleckstrin Homology Domains")

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Entity

Name
Pleckstrin Homology Domains
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Identification and Characterization of a G Protein-binding Cluster in alpha7 Nicotinic Acetylcholine Receptors v1.0.0

In-Edges 4

a(CHEBI:choline) association bp(MESH:"Pleckstrin Homology Domains") View Subject | View Object

Treatment of PC12 cells with 10 mM choline was associated with a translocation of PH-mCherry from the cell surface as determined by the presence of the fluorescence signal within 1 μm of the edge of the cell into the cytosol of the GC (Fig. 6, A and B). Pre-treatment of cells with SP abolished this translocation (Fig. 6B). PubMed:26088141

Appears in Networks:
Annotations
MeSH
Cytosol
MeSH
PC12 Cells

a(CHEBI:choline) increases bp(MESH:"Pleckstrin Homology Domains") View Subject | View Object

Sequential imaging of PH-mCherry and GCaMP5G confirms that choline promotes a rise in intracellular calcium and PH-mCherry translocation in the same cellular compartment (Fig. 6, B and C). Cytoplasmic translocation of PH-mCherry occurred on a slower time scale (40 s after choline application) than peak calcium responses (∼1 s after choline application). These kinetics are consistent with the translocation of the PH domain sensor in the cell (20, 29). PubMed:26088141

Appears in Networks:
Annotations
MeSH
Cytosol

a(MESH:"GP Antagonist-2A peptide") decreases bp(MESH:"Pleckstrin Homology Domains") View Subject | View Object

Treatment of PC12 cells with 10 mM choline was associated with a translocation of PH-mCherry from the cell surface as determined by the presence of the fluorescence signal within 1 μm of the edge of the cell into the cytosol of the GC (Fig. 6, A and B). Pre-treatment of cells with SP abolished this translocation (Fig. 6B). PubMed:26088141

Appears in Networks:
Annotations
MeSH
Cytosol
MeSH
PC12 Cells

p(HGNC:CHRNA7, var("p.345A"), var("p.346A"), var("p.347A"), var("p.348A")) decreases bp(MESH:"Pleckstrin Homology Domains") View Subject | View Object

In PC12 cells expressing α7345–348A nAChRs choline had a weak effect on PH-mCherry translocation relative to empty plasmid-transfected controls. Expression α7345–348A nAChRs was surprisingly associated with strong levels of PH-mCherry at the cell surface in the absence of drug treatment (Fig. 6B). PubMed:26088141

Appears in Networks:
Annotations
MeSH
Cytosol
MeSH
PC12 Cells

Out-Edges 1

bp(MESH:"Pleckstrin Homology Domains") association a(CHEBI:choline) View Subject | View Object

Treatment of PC12 cells with 10 mM choline was associated with a translocation of PH-mCherry from the cell surface as determined by the presence of the fluorescence signal within 1 μm of the edge of the cell into the cytosol of the GC (Fig. 6, A and B). Pre-treatment of cells with SP abolished this translocation (Fig. 6B). PubMed:26088141

Appears in Networks:
Annotations
MeSH
Cytosol
MeSH
PC12 Cells

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.