p(HBP:HBP00053, var("p.Ser262Glu"), var("p.Ser293Glu"), var("p.Ser324Glu"), var("p.Ser356Glu"))
The two pseudophosphorylated tau proteins (hTau40 AT8/AT100/PHF-1 and hTau40 4xKXGE) displayed significantly decreased lysosomal uptake when compared to hTau40 WT Tau (Fig. 7a,b) PubMed:29024336
This effect was more pronounced in the case of hTau40 4xKXGE, whose uptake and degradation by LE was completely abolished (Fig. 7d,e), suggesting that phosphorylation in the microtubule- binding domain diminishes its degradation by e-MI PubMed:29024336
The two pseudophosphorylated tau proteins (hTau40 AT8/AT100/PHF-1 and hTau40 4xKXGE) displayed significantly decreased lysosomal uptake when compared to hTau40 WT Tau (Fig. 7a,b) PubMed:29024336
This effect was more pronounced in the case of hTau40 4xKXGE, whose uptake and degradation by LE was completely abolished (Fig. 7d,e), suggesting that phosphorylation in the microtubule- binding domain diminishes its degradation by e-MI PubMed:29024336
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.