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path(MESH:"Lung Neoplasms")

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Entity

Name
Lung Neoplasms
Namespace
mesh
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/mesh-names.belns

Appears in Networks 3

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

In-Edges 7

p(HGNC:CHRNA3, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

p(HGNC:CHRNA5, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

p(HGNC:CHRNB4, var("?")) positiveCorrelation path(MESH:"Lung Neoplasms") View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

g(HGNC:CHRNA3) association path(MESH:"Lung Neoplasms") View Subject | View Object

interestingly, three independent studies have mapped susceptibility loci for lung cancer at nAChR genes: CHRNA5, CHRNA3 and CHRNB4 (ReFS 205–207). PubMed:19721446

Appears in Networks:
Annotations
MeSH
Corpus Striatum
Text Location
Review

g(HGNC:CHRNA5) association path(MESH:"Lung Neoplasms") View Subject | View Object

interestingly, three independent studies have mapped susceptibility loci for lung cancer at nAChR genes: CHRNA5, CHRNA3 and CHRNB4 (ReFS 205–207). PubMed:19721446

Appears in Networks:
Annotations
MeSH
Corpus Striatum
Text Location
Review

g(HGNC:CHRNB4) association path(MESH:"Lung Neoplasms") View Subject | View Object

interestingly, three independent studies have mapped susceptibility loci for lung cancer at nAChR genes: CHRNA5, CHRNA3 and CHRNB4 (ReFS 205–207). PubMed:19721446

Appears in Networks:
Annotations
MeSH
Corpus Striatum
Text Location
Review

g(DNSNP:rs1051730) association path(MESH:"Lung Neoplasms") View Subject | View Object

Human genetic studies have shown that the non- synonymous coding SNP D398N is associated with lung cancer and nicotine dependence PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

Out-Edges 10

path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA5, var("?")) View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNA3, var("?")) View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

path(MESH:"Lung Neoplasms") positiveCorrelation p(HGNC:CHRNB4, var("?")) View Subject | View Object

Single-nucleotide polymorphisms found in the human alpha5, alpha3, beta4 gene cluster are associated with nicotine dependence and its age-dependent onset; number of cigarettes smoked per day and ‘‘pleasurable buzz’’ elicited by smoking; alcoholism, sensitivity to the depressant effects of alcohol, and age of alcohol initiation; cocaine dependence; opioid dependence; lung cancer; and cognitive flexibility (Erlich et al., 2010; Hansen et al., 2010; Improgo et al., 2010; Saccone et al., 2010; Zhang et al., 2010) PubMed:21482353

Appears in Networks:

path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA5) View Subject | View Object

interestingly, three independent studies have mapped susceptibility loci for lung cancer at nAChR genes: CHRNA5, CHRNA3 and CHRNB4 (ReFS 205–207). PubMed:19721446

Appears in Networks:
Annotations
MeSH
Corpus Striatum
Text Location
Review

path(MESH:"Lung Neoplasms") association g(HGNC:CHRNA3) View Subject | View Object

interestingly, three independent studies have mapped susceptibility loci for lung cancer at nAChR genes: CHRNA5, CHRNA3 and CHRNB4 (ReFS 205–207). PubMed:19721446

Appears in Networks:
Annotations
MeSH
Corpus Striatum
Text Location
Review

path(MESH:"Lung Neoplasms") association g(HGNC:CHRNB4) View Subject | View Object

interestingly, three independent studies have mapped susceptibility loci for lung cancer at nAChR genes: CHRNA5, CHRNA3 and CHRNB4 (ReFS 205–207). PubMed:19721446

Appears in Networks:
Annotations
MeSH
Corpus Striatum
Text Location
Review

path(MESH:"Lung Neoplasms") association g(DNSNP:rs1051730) View Subject | View Object

Human genetic studies have shown that the non- synonymous coding SNP D398N is associated with lung cancer and nicotine dependence PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA9) View Subject | View Object

Lee et al. [122] have found that α9 nAChRs are ubiquitously expressed in many epithe- lial, lung and breast cancer cell lines, most of which also express α5 and α10 nAChR subunits. α9 nAChRs are also present in primary tumour and non-malignant breast tissue obtained from patients, but their expression is higher in breast cancer cells than the surrounding normal tissue. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) View Subject | View Object

Lee et al. [122] have found that α9 nAChRs are ubiquitously expressed in many epithe- lial, lung and breast cancer cell lines, most of which also express α5 and α10 nAChR subunits. α9 nAChRs are also present in primary tumour and non-malignant breast tissue obtained from patients, but their expression is higher in breast cancer cells than the surrounding normal tissue. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA10) View Subject | View Object

Lee et al. [122] have found that α9 nAChRs are ubiquitously expressed in many epithe- lial, lung and breast cancer cell lines, most of which also express α5 and α10 nAChR subunits. α9 nAChRs are also present in primary tumour and non-malignant breast tissue obtained from patients, but their expression is higher in breast cancer cells than the surrounding normal tissue. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.