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p(HGNC:CHRNA5)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CHRNA5
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 10

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection. v1.0.0

The Nicotinic Acetylcholine Receptor: The Founding Father of the Pentameric Ligand-gated Ion Channel Superfamily v1.0.1

Alzheimer's Disease: Targeting the Cholinergic System v1.0.0

Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications v1.0.0

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

In-Edges 12

complex(p(HGNC:CHRNA3), p(HGNC:CHRNA5), p(HGNC:CHRNB4)) hasComponent p(HGNC:CHRNA5) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7)) hasComponent p(HGNC:CHRNA5) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA4), p(HGNC:CHRNA5), p(HGNC:CHRNB2)) hasComponent p(HGNC:CHRNA5) View Subject | View Object

Appears in Networks:

complex(a(MESH:Bungarotoxins), p(HGNC:CHRNA5)) hasComponent p(HGNC:CHRNA5) View Subject | View Object

Appears in Networks:

p(FPLX:CHRN) hasMember p(HGNC:CHRNA5) View Subject | View Object

Appears in Networks:

p(GFAM:"Cholinergic receptors nicotinic subunits") hasMember p(HGNC:CHRNA5) View Subject | View Object

Appears in Networks:

act(a(CHEBI:nicotine)) association p(HGNC:CHRNA5) View Subject | View Object

Moreover, nAChRs containing β4, α2 and α5 in the habenulo-interpeduncular systems are necessary for nicotine withdrawal in mice107 PubMed:19721446

Appears in Networks:
Annotations
MeSH
Corpus Striatum
Text Location
Review

bp(HBP:"habenulo-interpeduncular pathway") increases p(HGNC:CHRNA5, loc(MESH:"Central Nervous System")) View Subject | View Object

The Hb-IPN system expresses the highest levels and va- riety of nAChR subunits and subtypes in mammalian brain [85], and is the only central system expressing high levels of α3, β4 and α5 subunits. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

complex(p(HGNC:CHRNA3), p(HGNC:CHRNA5), p(HGNC:CHRNB2), p(HGNC:CHRNB4)) hasComponent p(HGNC:CHRNA5) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA5), p(HGNC:CHRNA7), p(HGNC:CHRNB2), p(HGNC:CHRNB3), p(HGNC:CHRNB4)) hasComponent p(HGNC:CHRNA5) View Subject | View Object

Appears in Networks:

path(MESH:"Breast Neoplasms") increases p(HGNC:CHRNA5) View Subject | View Object

Lee et al. [122] have found that α9 nAChRs are ubiquitously expressed in many epithe- lial, lung and breast cancer cell lines, most of which also express α5 and α10 nAChR subunits. α9 nAChRs are also present in primary tumour and non-malignant breast tissue obtained from patients, but their expression is higher in breast cancer cells than the surrounding normal tissue. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

path(MESH:"Lung Neoplasms") increases p(HGNC:CHRNA5) View Subject | View Object

Lee et al. [122] have found that α9 nAChRs are ubiquitously expressed in many epithe- lial, lung and breast cancer cell lines, most of which also express α5 and α10 nAChR subunits. α9 nAChRs are also present in primary tumour and non-malignant breast tissue obtained from patients, but their expression is higher in breast cancer cells than the surrounding normal tissue. PubMed:28901280

Appears in Networks:
Annotations
MeSH
GABAergic Neurons

Out-Edges 4

p(HGNC:CHRNA5) decreases path(MESH:"Inflammatory Bowel Diseases") View Subject | View Object

Notably, mice with a null mutation in the gene that encodes the alpha5 nAChR subunit exhibit enhanced sensitivity to induction of inflammatory bowel disease relative to controls (353). Despite increased sensitivity to disease initiation, administration of transdermal nicotine remains effective in attenuating the disease process. Therefore, again nicotine appears to impact on inflammatory processes with considerable specificity and tissue dependency. PubMed:19126755

Appears in Networks:
Annotations
Text Location
Review

p(HGNC:CHRNA5) increases a(MESH:"Receptors, Nicotinic") View Subject | View Object

On the other hand, neuronal nicotinic receptors are formed by the combination of only two types of subunits (α2-10 and β2-4) PubMed:26813123

Appears in Networks:
Annotations
MeSH
Neurons

p(HGNC:CHRNA5) hasVariant p(HGNC:CHRNA5, var("?")) View Subject | View Object

Appears in Networks:

p(HGNC:CHRNA5) association act(a(CHEBI:nicotine)) View Subject | View Object

Moreover, nAChRs containing β4, α2 and α5 in the habenulo-interpeduncular systems are necessary for nicotine withdrawal in mice107 PubMed:19721446

Appears in Networks:
Annotations
MeSH
Corpus Striatum
Text Location
Review

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.