1. Catalog
  2. Nodes
  3. p(RGD:Mapt)

p(RGD:Mapt)

Equivalencies: 0 | Classes: 2 | Children: 0 | Explore

Entity

Name
Mapt
Namespace
rgd
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/rgd-names.belns

Appears in Networks 4

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers v1.0.0

This document contains the bel code for the Article Alzheimer’s disease-type neuronal tau hyperphosphorylation induced by Abeta oligomers by De Felice et al

TAU and Interaction Partners v1.2.5

TAU Interactions Section of NESTOR

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 4

act(p(HGNCGENEFAMILY:Proteasome)) increases deg(p(RGD:Mapt)) View Subject | View Object

For example, in the study where rat brain extract was incubated with Mg2+ and ATP, there was an overall decrease in tau due to proteasomal activity; however tau phosphorylated at the PHF1 and Tau-1 epitopes seemed to be preferentially degraded as they were non-detectable within 3 h (73). The preferential degradation of specific phospho-forms of tau by a particular pathway has been reported in other studies as well. PubMed:24027553

Appears in Networks:
Annotations
MeSH
Brain
Text Location
Review

complex(p(RGD:Klc1), p(RGD:Mapt)) hasComponent p(RGD:Mapt) View Subject | View Object

Appears in Networks:

p(RGD:Fkbp4) decreases act(p(RGD:Mapt)) View Subject | View Object

We concluded that FKBP52 inhibits the promotion of microtubule assembly by Tau. PubMed:20133804

Appears in Networks:

complex(p(RGD:Klc2), p(RGD:Mapt)) hasComponent p(RGD:Mapt) View Subject | View Object

Appears in Networks:

Out-Edges 16

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) isA complex(p(RGD:Klc1), p(RGD:Mapt)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) isA complex(p(RGD:Klc2), p(RGD:Mapt)) View Subject | View Object

Appears in Networks:

act(p(RGD:Mapt)) increases bp(GO:"microtubule polymerization") View Subject | View Object

We concluded that FKBP52 inhibits the promotion of microtubule assembly by Tau. PubMed:20133804

Appears in Networks:

act(p(RGD:Mapt)) increases bp(GO:"neuron projection development") View Subject | View Object

Because one role of Tau is to stimulate neurite outgrowth (12), we investigated the consequence of FKBP52 overexpression on neurite length in both PC12 and H7C2 cells. The inhibition of neurite outgrowth resulting from FKBP52 overexpression is in agreement with our previous report showing that the loss of FKBP52 in PC12 cells results in the formation of neurite extensions (9). The FKBP52 effect on neurite length could be explained by the binding of Tau to FKBP52, removing Tau from microtubules. PubMed:20133804

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(HBP:nitration)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Ser, 202)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Ser, 422)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Tyr, 18)) View Subject | View Object

Appears in Networks:

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Sumo)) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.