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p(RGD:Mapt, pmod(Ph, Ser, 396))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
Mapt
Namespace
rgd
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/rgd-names.belns

Appears in Networks 1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

act(p(RGD:Cdk5)) directlyIncreases p(RGD:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

In NGF-exposed PC12 cells, Egr-1 activates Cdk5 to promote phosphorylation of tau and inactivates PP1 via phosphorylation. Cdk5 phosphorylates Ser(396/404) directly. By phosphorylating and inactivating PP1, Cdk5 promotes tau phosphorylation at Ser(262) indirectly. PubMed:21489990

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
PC12

p(RGD:Mapt) hasVariant p(RGD:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

Out-Edges 0

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.