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m(MIRBASE:"hsa-mir-146a")

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Entity

Name
hsa-mir-146a
Namespace
mirbase
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mirbase-names.belns

Appears in Networks 1

Upstream regulators and downstream effectors of NF-κBinAlzheimer's disease v1.0.0

In-Edges 4

bp(GO:"immune response") association m(MIRBASE:"hsa-mir-146a") View Subject | View Object

Elevated miRNA-146a in AD brain has been shown to also specifically target the interleukin-1 associated ki- nase-1 (IRAK-1) mRNAs, it is believed to contribute to altered innate immune responses and neuroinflammation in degenerating human brain cells and tissues in inflammatory neurodegenerative diseases including AD and in primary human brain cells stressed with ROS- generating metal sulfates [69]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neurodegenerative Diseases

p(FPLX:NFkappaB) increases m(MIRBASE:"hsa-mir-146a") View Subject | View Object

Inducible miRNAs and lncRNA perform critical regulatory roles in CNS development, several brain-enriched miRNAs are consistently up- regulated by NF-κB, including miRNA-125b [66], miRNA-146a [67] and miRNA-155 [68]. PubMed:27288790

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation m(MIRBASE:"hsa-mir-146a") View Subject | View Object

Elevated miRNA-146a in AD brain has been shown to also specifically target the interleukin-1 associated ki- nase-1 (IRAK-1) mRNAs, it is believed to contribute to altered innate immune responses and neuroinflammation in degenerating human brain cells and tissues in inflammatory neurodegenerative diseases including AD and in primary human brain cells stressed with ROS- generating metal sulfates [69]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Brain

r(HGNC:IRAK1) association m(MIRBASE:"hsa-mir-146a") View Subject | View Object

Elevated miRNA-146a in AD brain has been shown to also specifically target the interleukin-1 associated ki- nase-1 (IRAK-1) mRNAs, it is believed to contribute to altered innate immune responses and neuroinflammation in degenerating human brain cells and tissues in inflammatory neurodegenerative diseases including AD and in primary human brain cells stressed with ROS- generating metal sulfates [69]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neurodegenerative Diseases

Out-Edges 4

m(MIRBASE:"hsa-mir-146a") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Elevated miRNA-146a in AD brain has been shown to also specifically target the interleukin-1 associated ki- nase-1 (IRAK-1) mRNAs, it is believed to contribute to altered innate immune responses and neuroinflammation in degenerating human brain cells and tissues in inflammatory neurodegenerative diseases including AD and in primary human brain cells stressed with ROS- generating metal sulfates [69]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Brain

m(MIRBASE:"hsa-mir-146a") association r(HGNC:IRAK1) View Subject | View Object

Elevated miRNA-146a in AD brain has been shown to also specifically target the interleukin-1 associated ki- nase-1 (IRAK-1) mRNAs, it is believed to contribute to altered innate immune responses and neuroinflammation in degenerating human brain cells and tissues in inflammatory neurodegenerative diseases including AD and in primary human brain cells stressed with ROS- generating metal sulfates [69]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neurodegenerative Diseases

m(MIRBASE:"hsa-mir-146a") association bp(GO:"immune response") View Subject | View Object

Elevated miRNA-146a in AD brain has been shown to also specifically target the interleukin-1 associated ki- nase-1 (IRAK-1) mRNAs, it is believed to contribute to altered innate immune responses and neuroinflammation in degenerating human brain cells and tissues in inflammatory neurodegenerative diseases including AD and in primary human brain cells stressed with ROS- generating metal sulfates [69]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neurodegenerative Diseases

m(MIRBASE:"hsa-mir-146a") increases path(HP:Neurodegeneration) View Subject | View Object

Elevated miRNA-146a in AD brain has been shown to also specifically target the interleukin-1 associated ki- nase-1 (IRAK-1) mRNAs, it is believed to contribute to altered innate immune responses and neuroinflammation in degenerating human brain cells and tissues in inflammatory neurodegenerative diseases including AD and in primary human brain cells stressed with ROS- generating metal sulfates [69]. PubMed:27288790

Appears in Networks:
Annotations
MeSH
Brain
MeSH
Neurodegenerative Diseases

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.